Copyright
©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2007; 13(11): 1715-1722
Published online Mar 21, 2007. doi: 10.3748/wjg.v13.i11.1715
Published online Mar 21, 2007. doi: 10.3748/wjg.v13.i11.1715
Table 1 General characteristics of patients with Hashimoto’s thyroiditis and patients with coeliac disease
| Characteristics | Patients with | Patients with |
| Hashimoto’s thyroiditis | coeliac disease | |
| n = 104 | n = 184 | |
| Mean (range) age, yr | 46 (20-74) | 53 (18-82) |
| Mean (range) age at diagnosis, yr | 42 (12-72) | 43 (3-76) |
| Men, n (%) | 13 (13%) | 46 (25%) |
| mean ± SD BMI | 25.9 ± 5.3 | 22.2 ± 2.8 |
| Caucasians, n (%) | 90 (86) | 168 (92) |
| Family history of Hashimoto’s thyroiditis or coeliac disease | 19% | 21% |
Table 2 Clinical characteristics, thyroid biochemistry, thyroid serology, and HLA-DQ data of patients with both Hashimoto’s thyroiditis and coeliac disease compared to patients with Hashimoto’s thyroiditis only
| Characteristics | Patients with only | Patients with both coeliac disease | P |
| Hashimoto’s thyroiditis | and Hashimoto’s thyroirditis | ||
| n = 99 | n = 27 | ||
| Presence of goiter, n (%) | 19 (19) | 4 (15) | > 0.05 |
| Presence of autoimmune diseases, n (%) | 11 (11) | 7 (26) | < 0.01 |
| Thyroid function test | |||
| mean ± SD TSH (normal 0.30-4.00 mU/L) | 24 (± 7.6) | 16 (± 5.8) | < 0.05 |
| mean ± SD Free T4 (normal 11-22 pmol/L) | 10 (± 4.1) | 12 (± 5.2) | > 0.05 |
| Positive thyroid serological tests, n (%) | |||
| Thyroglobulin (TG) | 35 (36) | 11 (41) | > 0.05 |
| Thyroid peroxidase (TPO) | 93 (94) | 25 (92) | > 0.05 |
| HLA-DQ 2 and/or -DQ8, n (%) | 53 (53) | 27 (100) | < 0.01 |
| DQ2 heterozygote | 30 (30) | 20 (74) | < 0.01 |
| DQ2 homozygote | 1 (1) | 3 (11) | < 0.01 |
| DQ8 heterozygote | 22 (22) | - | - |
| Combined DQ2 & DQ8 | 10 (10) | 4 (15) | > 0.05 |
Table 3 Comparison between patients with both Hashimoto’s thyroiditis and coeliac disease compared to patients with coeliac disease only
| Characteristics | Patients with only | Patients with both coeliac disease | P |
| coeliac disease | and Hashimoto’s thyroirditis | ||
| n = 140 | n = 27 | ||
| Positive any or combinations of coeliac serology, n (%) | 60 (43) | 16 (59) | < 0.05 |
| IgA anti-gliadin | 43 (31) | 12 (44) | < 0.05 |
| IgG anti-gliadin | 41 (29) | 16 (59) | < 0.01 |
| IgA anti-tissue transglutaminase | 43 (31) | 14 (50) | < 0.01 |
| IgA anti-endomysium | 46 (33) | 14 (52) | < 0.01 |
| Positive for HLA-DQ 2 and/or 8, n (%) | |||
| DQ2 heterozygote | 83 (59) | 20 (74) | < 0.05 |
| DQ2 homozygote | 38 (27) | 3 (11) | < 0.01 |
| DQ8 heterozygote | 9 (6) | - | - |
| DQ8 homozygote | 3 (2) | - | - |
| Combined DQ2 & DQ8 | 7 (5) | 4 (15) | < 0.05 |
| Small bowel histology, n (%) | |||
| Marsh 0 | 13 (9) | - | - |
| Marsh I | 13 (9) | 2 (7) | > 0.05 |
| Marsh II | 6 (4) | 2 (7) | > 0.05 |
| Marsh IIIa | 49 (35) | 12 (44) | > 0.05 |
| Marsh IIIb | 42 (30) | 6 (22) | > 0.05 |
| Marsh IIIc | 17 (12) | 5 (19) | > 0.05 |
| Villous atrophy | 108 (77) | 23 (85) | > 0.05 |
| Presence of autoimmune diseases, n (%) | 5 (4) | 7 (26) | < 0.01 |
- Citation: Hadithi M, de Boer H, Meijer JW, Willekens F, Kerckhaert JA, Heijmans R, Peña AS, Stehouwer CD, Mulder CJ. Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa. World J Gastroenterol 2007; 13(11): 1715-1722
- URL: https://www.wjgnet.com/1007-9327/full/v13/i11/1715.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i11.1715