Upregulation of hypoxia inducible factor 1α mRNA is associated with elevated vascular endothelial growth factor expression and excessive angiogenesis and predicts a poor prognosis in gastric carcinoma

Table 1 Correlation between expression of HIF-1α mRNA, VEGF and MVD and pathologic parameters in 118 patients with gastric carcinoma

Clinicopathologic index	n	HIF-1αmRNA				χ2	VEGF				χ2	MVD	t
		-	+	++	+++		-	+	++	+++		(/0.72 mm2)
Type of tumor						14.5					23.75
papillary adenocarcinomas	19	12	3	2	2		13	0	2	4		34.35 ± 17.47
Tubular adenocarcinomas	39	20	2	5	12		19	0	12	8		40.20 ± 14.84
Poorly differentiated adenocarcinomas	37	16	1	7	13		16	2	10	9		40.24 ± 15.47
Signet-ring cell carcinomas	11	5	0	0	6		2	2	2	5		48.63 ± 12.28
Mucinous adenocarcinomas	12	7	0	2	3		2	2	2	6		48.98 ± 10.41
Degree of differentiation						4.48					2.65		1.26
Well or moderately	70	39	5	9	17		34	2	16	18		40.12 ± 15.52
differentiated adenocarcinomas
Poorly differentiated and	48	21	1	7	19		18	4	12	14		43.70 ± 14.93
undifferentiated adenocarcinomas
Depth of invasion						24.22					30.05		6.23
T1-T2	47	36	3	1	7		35	2	4	6		31.98 ± 14.37
T3-T4	71	24	3	15	29		17	4	24	26		47.93 ± 12.41
Vessel invasion						22.03					43.06		9.04
No	29	24	3	0	2		28	0	0	1		25.69 ± 10.11
Yes	89	36	3	16	34		24	6	28	31		46.75 ± 13.01
Lymph node metastasis						18.99					35.52		8.77
No	35	27	3	0	5		30	1	1	3		27.07 ± 11.33
Yes	83	33	3	16	31		22	5	27	29		47.69 ± 12.41
Distant metastasis						72.06					61.71		12.91
No	63	52	6	2	3		48	4	5	6		30.81 ± 12.43
Yes	55	8	0	14	33		4	2	23	26		53.91 ± 6.42

Table 2 Relationship between HIF-1α mRNA, VEGF and MVD value and prognosis of gastric carcinoma

Groups	n	Mean survival time (mo)	5-yr survival (%)
HIF-1α mRNA
-	60	127 ± 10.25	82.72
+	58	37 ± 12.65	25.67
VEGF
-	52	117 ± 11.32	75.35
+	66	45 ± 10.82	21.22
MVD (/0.72 mm2)
< 41.5	76	130 ± 10.72	83.75
≥ 41.5	42	43 ± 11.78	20.42