Apoptosis induced by preoperative oral 5’-DFUR administration in gastric adenocarcinoma and its mechanism of action

Table 1 Expression of PI, AI, Fas/ FasL compared to operation procedure, early or advanced tumor, T, N, M and UICC stages

	PI AI	Fas	FasL	PD-ECGF
	(%) (%)	+ -	+ -	+ -
Way of resection
radical	46.31±15.30 12.13±9.65	26 16	29 13	19 23
Palliation	50.74±21.27 9.40±8.35	2 10	10 2	7 5
P/χ2 Value	0.654 0.791	7.651	0.949	0.641
P Value	0.422 0.378	0.006	0.33	0.423
Early cancer
Yes	45.29±12.34 14.54±12.38	7 2	6 3	3 6
No	47.70±17.51 10.92±8.70	21 24	33 12	23 22
F/χ2 Value	0.154 1.123	2.908	0.166	0.949
P Value	0.697 0.294	0.088	0.684	0.33
Invasion depth
T1-2	46.65±15.76 11.96±9.81	20 8	19 9	12 16
T3-4	47.99±17.92 11.06±9.04	8 18	20 6	14 12
F/χ2 Value	0.086 0.121	8.927	0.552	0.652
P Value	0.770 0.729	0.003	0.457	0.419
Lymphonode
N0	50.37±16.34 10.51±9.89	13 5	14 4	9 9
N1-4	45.76±16.87 12.03±9.20	15 21	25 11	17 19
F/χ2 value	0.917 0.312	4.488	0.415	0.037
P value	0.343 0.579	0.034	0.519	0.847
Metastasis
M0	46.73±15.79 11.51±9.10	26 19	33 12	22 23
M1	50.10±21.5 11.60±11.24	7 2	6 3	4 5
F/χ2 value	0.301 0.001	3.798	0.166	0.059
P value	0.585 0.980	0.051	0.684	0.808
UICC stage
I	50.42±16.84 10.98±9.99	13 4	13 4	9 8
II	42.69±13.24 11.78±10.65	5 4	6 3	2 7
III	46.03±16.2 12.73±10.10	7 9	11 5	7 9
IV	48.01±20.18 10.52±7.25	3 9	9 3	8 4
F/χ2 value	0.452 0.148	8.063	0.434	4.352
P value	0.717 0.931	0.045	0.933	0.226

Table 2 Influence of preoperative chemotherapy on expression of Fas/FasL, PD-ECGF and AI, PI

Group N	Fas	FasL	PI	AI	PD-ECGF + -
	+ -	+ -	(%)	(%)
5’-DFUR 18	12 6	9 9	40.51 ± 12.62	14.39 ± 9.49	4 14
CF+5-FU   16	7 9	13 3	41.12 ± 15.26	14.11 ± 9.68	9 7
Control 20	9 11	17 3	58.33 ± 15.69	6.88 ± 7.37	13 7
X2/F value	2.379	6.708	9.083	4.409	7.542
P value	0.304	0.035	0	0.017	0.023