Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men

Table 1 Serum levels of Total cholesterol (TC) and Triglyceride (TG) in patients with tubular, villous and serrated adenomas

Pathological finding	TC	n	P value	TG	n	P value
tubular adenoma
abesnt	199.6 ± 34.4	958		108.9 ± 71.0	954
present	207.3  ± 29.3	3925	P < 0.0001	135.8 ± 81.8	3920	P < 0.0001
villous adenoma
abesnt	205.8 ± 30.6	4831		130.5 ± 80.7	4821
present	211.5 ± 24.6	52	N	132.0 ± 60.8	53	NS
serrated adenoma
abesnt	205.8 ± 30.6	4848		130.4 ± 80.3	4838
present	208.8 ± 24.1	35	NS	149.3 ± 102.3	36	NS

NS: not significant.

Table 2 Univariate analysis of risk factors for tubular adenoma

Tubular adenoma		Total	Negative (%)	Positive (%)	P value
Age (yr)
	10-56	2475	765 (30.9)	1710 (69.1)
	57-94	2412	194 (8.0)	2218 (92.0)	< 0.0001
Gender
	Male	2997	402 (13.4)	2595 (86.6)
	Female	1890	557 (29.5)	1333 (70.5)	< 0.0001
Hypercholesterolemia
	Negative	3318	695 (21.0)	2623 (79.0)
	Positive	1565	263 (16.8)	1302 (83.2)	< 0.0001
	Unknown	4
Hypertriglyceridemia
	Negative	3488	784 (22.5)	2704 (77.5)
	Positive	1386	170 (12.3)	1216 (87.7)	< 0.0001
	Unknown	13

Hypercholesterolemia and hypertriglyceridemia were defined as total cholesterol>220mg/dL and TG>150 mg/dL, respectively.

Table 3 Adjusted odds ratios and 95% CIs for tubular adenoma for a change of 1SD in male or female patients

	TC			TG
	OR	95% CI	P value	OR	95% CI	P value
Total (3787)
Gross OR	1.3	1.21-1.39	< 0.0001	1.64	1.48-1.82	< 0.0001
Age adjusted OR	1.01	0.93-1.09	0.79	1.34	1.21-1.48	< 0.0001
Age, gender and TC or TG adjusted OR	1.04	0.96-1.13	0.334	1.13	1.01-1.09	0.013
Male (2997)
Gross OR	1.32	1.19-1.47	< 0.0001	1.35	1.19-1.56	< 0.0001
Age adjusted OR	1.09	0.98-1.23	0.13	1.24	1.09-1.43	0.0015
Age and TC or TG adjusted OR	1.04	0.91-1.07	0.555	1.23	1.07-1.42	0.0041
Female (1890)
Gross OR	1.49	1.34-1.65	< 0.0001	1.42	1.25-1.64	< 0.0001
Age adjusted OR	1.08	0.96-1.21	0.21	1.04	0.92-1.17	0.56
Age and TC or TG adjusted OR	1.06	0.95-1.02	0.29	1.02	0.91-1.16	0.7