Review
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2006; 12(8): 1165-1174
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1165
Table 1 Relative risks and comparison of common thrombophilic conditions[21,22].
Thrombophilic conditionRelative risk of thrombosis
Inherited
Heterozygote deficiency of natural anticoagulants (PC, PS, AT)10-fold
Heterozygote FVLM5-8 fold
Homozygote FVLM50-80 fold
Heterozygote PM2-4 fold
Homozygote PM10-fold
Acquired
Oral contraceptive use4-fold
Surgery6-fold
Immobilization11-fold
Anti-phospholipid syndrome10-fold
Combined
Oral contraceptive use + Heterozygote FVLM35-fold
Table 2 Role of genetic thrombophilic factors in development of PVT
ThrombophilicfactorChamouradet al[41]Egeselet al[40]Janssenet al[39]Denningeret al[33]Primignaniet al[38]
n1032923665
FVLM103082,83
PM40NS131422
PC deficiencyNS26700
PS deficiencyNS432302
AT deficiencyNS2614,53