Mutation of RET proto-oncogene in Hirschsprung’s disease and intestinal neuronal dysplasia

Table 1 Mutations of RET proto-oncogene in HD and IND patients

Case	Group	Exon	Nucleotide change	Amino acid change	Mutation type
1	HD	11	G15165→A	G667S	Missense mutation
2	HD	11	G15165→A	G667S	Missense mutation
3	HD	13	18974insG	---	Frameshift mutation
4	HD	13	18974insG	---	Frameshift mutation
5	HD	13	A18919→G	K756E	Missense mutation
6	HD	15	G20692→A	Q916Q	Silent mutation
7	HD/IND	11	G15165→A	G667S	Missense mutation
8	HD/IND	13	T18888→G	L745L	Silent mutation