Low central venous pressure reduces blood loss in hepatectomy

Table 1 Comparison of patient’s clinical data between two groups

Groups	Gender (male/female)1	Age (yr)2	Body weight (kg)3	Liver cirrhosis (n)4	Liver function (Child-Pugh class)5
					A	B	C
LCVP	19/6	45.33 ± 14.59	60.11 ± 12.14	14	21	3	1
Control	21/4	46.00 ± 12.14	59.91 ± 10.84	15	21	4	0

¹χ²=0.500,

²t=0.174,

³t=0.055,

⁴χ²=0.082,

⁵χ²=1.143.

Table 2 Comparison of blood routine examination, hepatic and renal functions, and coagulation function between two groups

Groups	Blood routine examination			Hepatic function			Coagulation function	Renal function
	Hb(g/L)	RBC(×1012/L)	HCT	ALT(μ/L)	TBIL(μmol/L)	ALB(g/L)	PT(s)	BUNa(mmol/L)	Cr(μmol/L)
LCVP	134.08 ± 19.17	4.632 ± 0.83	0.41 ± 0.058	51.24 ± 29.91	29.04 ± 42.71	41.29 ± 6.13	12.56 ± 1.12	4.75 ± 1.24	69.04 ± 15.72
Control	136.48 ± 13.51	4.58 ± 0.55	0.41 ± 0.039	61.36 ± 47.51	22.64 ± 11.27	41.12 ± 4.79	12.53 ± 1.16	5.48 ± 1.12	70.76 ± 17.99
t	0.512	0.292	0.233	0.901	0.724	573.00	0.087	2.096	0.360

^aP<0.05, BUN values in both groups were within normal range (2.5-6.4 mmol/L).

Table 3 Comparison of operative pattern between two groups

Groups	Types of hepatectomy1				Types of vascular occlusions			Maximal tumor	Weight of the resected
					(n)2		time (min)3	dimension (cm)4	liver tissues (g)
	Right	Left	≥2 hepaticsegments	Single hepaticsegments	Unilateral	Portalhepatitis
LCVP	5	3	13	4	4	7	20.00±12.17	10.7±4.9	633.80±567.38
Control	4	5	10	6	2	11	17.27±6.56	9.88±4.2	603.20±497.62

¹χ²=1.402,

²χ²=1.709,

³t=0.621,

⁴t=0.633, ⁵t=0.203.

Table 4 Comparison of intra-operative blood loss between two groups

Group	Pre-hepatectomy	Intra-hepatectomy	Post-hepatectomy2	Total
LCVP	318.2 ± 605.6	672.4 ± 429.9b	42 ± 35.4	903.9 ± 180.8d
Control	603.4 ± 973.7	1 662.6 ± 1 932.1	63.4 ± 52.9	2 329.4 ± 2 538.4
W1	495	543.5	538	495.5

¹Rank sum test;

²P = 0.05,

^bP < 0.01,

^dP < 0.01 vs control.

Table 5 Comparison of operation time and incidence of post-operative complications

Groups	Operation time (min)1	Intra- and post-operative transfusion (mL)		Incidence of post-operative complications (n)4
		Packed RBC2	FFP3
LCVP	229.60 ± 67.33	525.00 ± 237.57a	437.50 ± 250.36c	5
Control	246.00 ± 112.36	1 285.71 ± 1 162.13	1 057.14 ± 658.33	6

¹t=0.626;

²W=63.00,

³t=2.537,

⁴χ²=9.778,

^aP<0.05,

^cP<0.05 vs control.

Table 6 Comparison of post-operative hepatic and renal functions between two groups

Parameters	Postoperative day	LCVP	Control
ALT (μ/L)1	1	561.00 ± 409.23	700.76 ± 610.77
	3	286.4 ± 204.09	396.60 ± 423.86
	7	104.60 ± 56.18	173.04 ± 268.17
TBIL (μmol/L)2	1	29.04 ± 42.71	22.64 ± 11.27
	3	39.34 ± 47.08	40.46 ± 28.33
	7	23.69 ± 26.40	28.95 ± 30.82
BUN (mmol/L)3	1	4.75 ± 1.24	5.48 ± 1.12
	3	4.87 ± 2.59	5.72 ± 1.84
	7	5.10 ± 1.75	6.03 ± 2.23
Cr (μmol/L)4	1	69.04 ± 15.72	70.76 ± 17.99
	3	58.04 ± 15.68	65.28 ± 17.67
	7	59.12 ± 11.57	60.96 ± 15.60

¹F = 72.955,

²F = 0.185,

³F = 0.860,

⁴F = 6.462.