Relationship between therapeutic efficacy of arterial infusion chemotherapy and expression of P-glycoprotein and p53 protein in advanced hepatocellular carcinoma

Table 1 Patient characteristics

		Anthracycline group	Non-anthracycline group
Age (yr)	Mean	60.5 ± 7.2	62.1 ± 8.8
Gender1	Male	18	19
	Female	2	2
Tumor stage12	III	1	1
	IV	19	20
Child’s class1	A	12	11
	B	6	9
	C	2	1
Hepatitis virus1	B( - ) C( + )	15	14
	B( + ) C( + )	3	5
	B( + ) C( - )	0	1
	B( - ) C( - )	2	1
Chemotherapy13	( - )	13	13
	( + )	7	8
HCC differentiation1	Well	1	2
	Moderately	14	15
	Poorly	5	4

Not significant (Mann-Whitney U-test).

¹Number of patients.

²According to the criteria for tumor stage according to TNM classification (UICC).

³Chemoembolization with epirubicin hydrochloride.

Table 2 Correlation between positivity of PGP and that of p53 protein

	PGP positivity
Positivity	Strongly-positive	Weakly-positive	Negative
p53 strongly-positive	5	2	1
p53 weakly-positive	2	4	0
p53 negative	8	16	3
			Not significant (χ2)

Table 3 Correlation between PGP or p53 protein positivity and therapeutic efficacy by anticancer drugs

Positivity	Anthracycline group (n = 20)				Response rate (%) (95%CI)	Non-anthracycline group (n = 21)				Response rate (%) (95%CI)
	CR	PR	NC	PD		CR	PR	NC	PD
PGP12
Non-positive group	2	6	3	0	72.7 (46.4-99.1)b	3	5	5	2	53.3 (28.1-78.6)
Positive group	0	0	4	5	0.0 (0.0-0.0)	0	1	3	2	16.7 (-13.2-46.5)
p5313
Non-positive group	2	4	2	4	50.0 (21.7-78.3)	3	6	6	2	52.9 (29.2-76.7)
Positive group	0	2	5	1	25.0 (-5.0-55.0)	0	0	2	2	0.0 (0.0-0.0)

^bP < 0.01 vs positive group (χ²).

¹Number of patients.

²Non-positive group: negative and weakly positive. Positive group: strongly positive.

³Non-positive group: negative. Positive group: weakly positive and strongly positive.

Table 4 Correlation between PGP or p53 protein positivity and cumulative survival rates

Positivity	Number of patients		Survival rates (%)		Median survival	95%CI
		12 mo	24 mo	36 mo	time (mo)
Anthracycline group
PGP
Non-positive	11	90.9	54.6	9.1	26.5	15.8-37.2b
Positive	9	11.1	0.0	0.0	6.6	6.4-6.8
P53
Non-positive	12	58.3	41.7	8.3	18.3	0.0-41.4
Positive	8	50.0	12.5	0.0	9.7	0.0-20.7
Non-anthracycline group
PGP
Non-positive	15	80.0	53.3	33.3	24.5	13.3-35.8
Positive	6	50.0	16.7	16.7	9.3	0.0-21.2
P53
Non-positive	15	80.0	46.7	33.3	18.7	5.7-31.8
Positive	6	50.0	33.3	16.7	9.3	0.0-25.2

^bP < 0.01 vs positive group (log rank test).