Microproteinuria in patients with inflammatory bowel disease: Is it associated with the disease activity or the treatment with 5-aminosalicylic acid?

Table 1 Incidence of abnormal microproteinuria in patients with active and inactive IBD (%)

	Ulcerative colitis (n = 194)			Crohn's disease (n = 83)
	Active (n = 49)UCAI ≥ 6	Inactive (n = 145)UCAI < 6	P	Active (n = 15)CDAI ≥ 150	Inactive (n = 68)CDAI < 150	P
Urine m-ALB (>18 μg/min)	16.3	11.7	NS	13.3	4.4	0.06
Urine β2 mGLB (>120 μg/min)	40.8	16.6	< 0.001	53.3	22.1	< 0.05
Urine β-NAG (>5.9 U/L)	26.5	6.2	< 0.001	13.3	7.4	NS

Table 2 Microproteinuria and creatinine clearance in active and inactive IBD (mean±SE)

	Ulcerative colitis (n = 194)			Crohn's disease (n = 83)
	Active(n=49)	Inactive(n=145)	P	Active(n=15)	Inactive(n=68)	P
Urine m-ALB (μg/min)	11.89 ± 3.19	9.0 ± 1.03	NS	8.59 ± 2.65	7.02 ± 1.07	NS
Urine β2mGLB (μg/min)	204 ± 50.2	88.0 ± 10.28	<0.01	359 ± 130.9	92.2 ± 16.26	<0.05
Urine β-NAG (U/L)	4.69 ± 0.64	2.39 ± 0.16	<0.001	3.07 ± 0.90	2.36 ± 0.25	NS
Urine Kcr (mL/min)	114.4 ± 6.03	120.3 ± 3.24	NS	135.6 ± 8.34	127.7 ± 3.96	NS

NS: Not significant.

Table 4 Correlation between microproteinuria in patients with ulcerative colitis and disease activity parameters (n=194 measurements)

		Ulcerative colitis activity parameters
		UCAI	UCEI	CRP	ESR	Platelets	SerumTNF-α
Urine m-ALB	rS	0.0283	0.0420	0.0232	0.0091	0.0826	0.1665
(μg/min)	P	0.6954	0.5612	0.7479	0.9001	0.2520	0.0203
Urine β2mGLB	rS	0.1957	0.1037	0.1059	0.0033	0.0540	0.0123
(μg/min)	P	0.0062	0.1501	0.1414	0.9634	0.4543	0.8648
Urine β-NAG	rS	0.2633	0.2335	0.1438	0.1224	0.2336	0.1057
(U/L)	P	0.0002	0.0010	0.0455	0.0891	0.0010	0.1426

r_S: Spearman’s correlation coefficient; r_P: Pearson’s correlation coefficient.

Table 5 Correlation between microproteinuria in patients with Crohn’s disease and disease activity parameters (n=83 measurements)

		Crohn's disease activity parameters
		CDAI	CRP	ESR	Platelets	SerumTNF-α
Urine m-ALB	rS	0.1186	0.0326	0.0352	0.1483	0.1537
(μg/min)	P	0.2856	0.7686	0.7522	0.1810	0.1654
Urine β2mGLB	rS	0.0813	0.0187	0.0624	0.1727	0.2100
(μg/min)	P	0.4648	0.8669	0.5751	0.1184	0.0568
Urine β-NAG	rS	0.1106	0.0319	0.0947	0.0527	0.2676
(U/L)	P	0.3196	0.7744	0.3347	0.6359	0.0145

r_S: Spearman’s correlation coefficient; r_P: Pearson’s correlation coefficient.

Table 3 Correlation of microproteinuria and creatinine clearance of IBD patients after 5-ASA treatment (mean±SE)

	Ulcerative colitis (n=194)5-ASA treatment		P	Crohn's disease (n=83)5-ASA treatment		P
	No (n=37)	Yes (n=157)		No (n=15)	Yes (n=68)
Urine m-ALB (μg/min)	8.99 ± 2.10	9.90 ± 1.29	0.794	8.08 ± 2.57	7.13 ± 1.08	0.562
Urine β2mGLB (μg/min)	163 ± 61.16	107 ± 12.07	0.852	274 ± 129.2	111.0 ± 20.15	0.083
Urine β-NAG (U/L)	4.22 ± 0.82	2.67 ± 0.18	0.118	2.79 ± 0.91	2.42 ± 0.26	0.845
Urine Kcr (mL/min)	117 ± 7.25	119 ± 3.11	0.987	130 ± 7.62	129 ± 4.05	0.713