Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis

doi:10.3748/wjg.v12.i47.7705

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Dec 21, 2006 (publication date) through May 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2006; 12(47): 7705-7709
Published online Dec 21, 2006. doi: 10.3748/wjg.v12.i47.7705

Table 1 Grading of histological injury using microscopic injury score

Score	Findings
O	Normal
I	Notable cloudy swelling of tubular epithelial cells
II	Swelling denaturation of renal tubular epithelial cells, interstitial congestion, edema and infiltration of inflammatory cells
III	Diffuse coagulation necrosis in tubular epithelial cells

Table 2 Renal blood flow in groups C, P and T [mL/(min·g)] (mean ± SD, n = 8)

Group	0.5 h	2 h	6 h	12 h
C	7.33 ± 0.35	7.63 ± 0.43	7.46 ± 0.67	7.55 ± 0.67
P	5.67 ± 0.51^b	6.64 ± 0.68^b	5.81 ± 0.67^b	5.16 ± 0.72^b
T	7.17 ± 0.72	7.22 ± 0.82	7.22 ± 0.73^d	7.31 ± 1.12^d

^bP < 0.01 vs C group;

^dP < 0.01 vs P group.

Table 3 Serum BUN level in groups C, P and T (mean ± SD, mmol/L)

Group	0.5 h	2 h	6 h	12 h
C	9.80 ± 1.36	10.31 ± 1.50	10.05 ± 0.87	10.21 ± 1.33
P	11.99 ± 2.08^a	12.73 ± 1.72^a	14.71 ± 2.08^b	15.16 ± 2.73^b
T	10.12 ± 1.23^c	10.53 ± 2.25^c	11.52 ± 2.21^d	11.71 ± 1.31^d

^aP < 0.05,

^bP < 0.01 vs C group;

^cP < 0.05,

^dP < 0.01 vs P group.

Table 4 Serum Cr level in groups C, P and T (mean ± SD, mmol/L)

Group	0.5 h	2 h	6 h	12 h
C	21.12 ± 1.67	21.06 ± 1.58	21.50 ± 1.78	21.62 ± 1.75
P	24.97 ± 3.40^a	25.36 ± 3.11^b	30.40 ± 1.93^b	30.60 ± 2.04^b
T	22.13 ± 1.57^c	23.5 ± 2.61^a^c	23.58 ± 2.61^a^d	24.73 ± 1.01^b^d

^aP < 0.05,

^bP < 0.01 vs C group;

^cP < 0.05,

^dP < 0.01 vs P group.

Table 5 Serum level of TXA2/PGI2 in groups C, P and T (mean ± SD)

Group	0.5 h	2 h	6 h	12 h
C	1.18 ± 0.15	1.22 ± 0.11	1.24 ± 0.15	1.23 ± 0.16
P	1.23 ± 0.16	1.50 ± 0.21^b	1.61 ± 0.19^b	1.86 ± 0.28^b
T	1.19 ± 0.14	1.31 ± 0.14	1.31 ± 0.17^a^c	1.45 ± 0.24^a^d

^aP < 0.05,

^bP < 0.01 vs C group;

^cP < 0.05,

^dP < 0.01 vs P group.

Table 6 Renal tissue injury in groups C, P and T

Group	0.5 h				2 h				6 h				12 h
	0	I	II	III	0	I	II	III	0	I	II	III	0	I	II	III
C	8	0	0	0	8	0	0	0	8	0	0	0	8	0	0	0
P	0	1	3	4^b	0	0	4	4^b	0	0	3	5^b	0	0	0	8^b
T	4	4	0	0^d	0	3	5	0^d	1	2	2	3^d	0	1	3	4^c

^bP < 0.01 vs C group;

^cP < 0.05,

^dP < 0.01 vs P group.

Table 7 Renal tissue neutrophil infiltration in groups C, P and T (mean ± SD)

Group	0.5 h	2 h	6 h	12 h
C	5.5 ± 1.2	6.5 ± 1.2	6.7 ± 1.3	6.9 ± 1.4
P	13.0 ± 1.6^b	15.0 ± 1.9^b	18.0 ± 1.7^b	21.1 ± 3.0^b
T	6.9 ± 1.4	10.8 ± 1.4^b^d	13.0 ± 1.6^b^d	15.0 ± 2.0^b^d

^bP < 0.01 vs C group;

^dP < 0.01 vs P group.

Citation: Zhang JX, Dang SC, Qu JG, Wang XQ. Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis. World J Gastroenterol 2006; 12(47): 7705-7709
URL: https://www.wjgnet.com/1007-9327/full/v12/i47/7705.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i47.7705