Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis

doi:10.3748/wjg.v12.i47.7666

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Dec 21, 2006 (publication date) through Feb 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2006; 12(47): 7666-7670
Published online Dec 21, 2006. doi: 10.3748/wjg.v12.i47.7666

Table 1 Blood biochemical parameters

Parameter	Sham(n = 6)	SAP(n = 20)	HMGB1 Ab + SAP(n = 12)
Amylase (IU/L)	2220 ± 707	52 155 ± 14 449^a	8994 ± 1623^c
AST (IU/L)	1499 ± 335	5056 ± 545^a	4193 ± 561
ALT (IU/L)	395 ± 288	1215 ± 118^a	848 ± 145^c
LDH (IU/L)	6743 ± 1206	16403 ± 1072^a	15 220 ± 4687
BUN (mg/dL)	32 ± 3	93 ± 6^a	94 ± 7
Cr (mg/dL)	0.10 ± 0.00	0.42 ± 0.10^a	0.16 ± 0.03^c

Blood samples were obtained 12 h after induction of SAP. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; BUN: Blood urea nitrogen; Cr: Creatinine.

^aP < 0.05 vs Sham group;

^cP < 0.05 vs SAP group.

Citation: Sawa H, Ueda T, Takeyama Y, Yasuda T, Shinzeki M, Nakajima T, Kuroda Y. Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis. World J Gastroenterol 2006; 12(47): 7666-7670
URL: https://www.wjgnet.com/1007-9327/full/v12/i47/7666.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i47.7666