Effects of ketamine on proinflammatory cytokines and nuclear factor kappaB in polymicrobial sepsis rats

doi:10.3748/wjg.v12.i45.7350

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Dec 7, 2006 (publication date) through Feb 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2006; 12(45): 7350-7354
Published online Dec 7, 2006. doi: 10.3748/wjg.v12.i45.7350

Table 1 Changes of TNF-α, (pg/mL, n = 5, mean ± SD)

Group	Time point (after CLP)
Group	2h	5h	9h	20h
Sham CLP	4.3 ± 0.9^b	4.3 ± 0.9^b	5.0 ± 1.7^b	4.0 ± 0.9
CLP	27.3 ± 3.1	15.0 ± 2.0	10.7 ± 1.9	4.3 ± 0.9
KTI	14.3 ± 1.9^a^b	9.3 ± 1.5^b	6.0 ± 1.5^b	4.3 ± 1.5
KTII	9.7 ± 1.4^b	8.7 ± 1.4^b	5.3 ± 0.8^b	3.7 ± 0.8

^bP < 0.01 vs CLP group,

^aP < 0.05 vs ketamineIIgroup.

Table 2 Changes of IL-6, (pg/mL, n = 5, mean ± SD)

Group	Time point (after CLP)
Group	2h	5h	9h	20h
Sham CLP	50.0 ± 15.3	60.0 ± 16.3^b	62.5 ± 12.5^b	52.5 ± 10.1^b
CLP	52.5 ± 10.5	217.5 ± 25.9	882.5 ± 127.1	567.5 ± 144.9
KTI	50.0 ± 8.8	135.0 ± 52.6^a	410.0 ± 68.7^b^c	320.0 ± 25.9^b
KTII	45.0 ± 11.2	112.5 ± 52.6^b	250.0 ± 28.0^b	215.0 ± 44.6^b

^aP < 0.05,

^bP < 0.01 vs CLP group;

^cP < 0.05 vs ketamineIIgroup.

Table 3 Changes of NF-κB P65 absorbency, (n = 5, mean ± SD)

Group	4 h after CLP
Sham group	215.5 ± 2.7^b
CLP group	264.5 ± 7.4
KTIgroup	246.9 ± 3.1^a^b
KTIIgroup	237.7 ± 3.5^b

^aP < 0.05 vs ketamineIIgroup;

^bP < 0.01 vs CLP group.

Citation: Song XM, Li JG, Wang YL, Zhou Q, Du ZH, Jia BH, Ke JJ. Effects of ketamine on proinflammatory cytokines and nuclear factor kappaB in polymicrobial sepsis rats. World J Gastroenterol 2006; 12(45): 7350-7354
URL: https://www.wjgnet.com/1007-9327/full/v12/i45/7350.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i45.7350