Concept on the pathogenesis and treatment of primary biliary cirrhosis

Table 1 Levels of bile acids, cholesterol, lecithin, and orthophosphate in the hepatic bile portion and serum of patients with PBC (n = 16) and controls (n = 14)

Parameters		Values
		Controls (mean1± SE)	Patients with PBC (mean2± SE)	mean1/ mean2
Bile acids (g/L)	Bile	3.9 ± 0.8	0.65 ± 0.02	6.0
	Blood	0.012 ± 0.008	0.054 ± 0.008	-0.2
Cholesterol (μmol/L)	Bile	0.91 ± 0.06	0.38 ± 0.08	2.4
	Blood	4.2 ± 0.6	11.8 ± 1.6	-0.4
Lecithina	Bile	2.1 ± 0.3	0.5 ± 0.1	-4.6
Orthophosphatea	Bile	1.2 ± 0.3	0.30 ± 0.07	4.0

^a The data given in the table show the average statistical integral intensity of the corresponding ³¹Р NMR spectral signals in conditional units.

Table 2 Arithmetic means of the dissociation coefficient in different nosological forms of chronic diffuse hepatic lesions

Liver lesion	Cd (mean ± SD)	Cd ranges
PBC (n = 11)	0.61 ± 0.03b	0.41 ± 0.84
CH (n = 20)	0.14 ± 0.04	0.02-0.24
LC (n = 3)	0.18 ± 0.03	0.14-0.24
UH (n = 8)	0.11 ± 0.02	0.00-0.16
FH (n = 11)	0.07 ± 0.02	0.00-0.14
Controls (n = 16)	0.09 ± 0.02	0.00-0.18

CH: Chronic hepatitis of various etiology; PBC: Primary biliary cirrhosis; UH: Gilbert’s unconjugated hyperbilirubinemia; FH: Fatty hepatosis; LC: Liver cirrhosis;

^bP < 0.001 vs both the controls and other groups of the disease.