Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats

Table 1 Effect of amphetamine on incidence and severity of indomethacin-induced gastric ulcerations (%)

Groups		TU	LU	PR
I	I50	100	100
II	I50 + A10	88.89	77.778	(+) 24.138
III	I50 + A25	77.78	66.667	(+) 55.1721
V	I50 + A50	37.5a	12.5a	(+) 80.6031

The subscript indices represent the doses expressed as μmol/kg.I: Indomethacin; A: Amphetamine; TU: Total number of ulcerations; LU: Large ulcerations (> 1 mm); PR: Protection ratio.

^aP < 0.05 vs groupI(Fischer’s exact probability and median’s test);

¹Significant at PR > (+) 33.33%.

Table 2 Effect of amphetamine on number and severity of indomethacin-induced gastric ulcerations (mean ± SE)

Groups		Number ofulcerations/stomach		Severity
		TU	LU	UI
I (9)	I50	12.44 ± 3.69	10.11 ± 3.74	1.61 ± 0.31
II (9)	I50 + A10	7.33 ± 1.89	5.44 ± 1.52	1.22 ± 0.25
III (9)	I50 + A25	5.33 ± 2.38	3.11 ± 1.9	0.72 ± 0.21a
IV (8)	I50 + A50	2.25 ± 1.91c	1.0 ± 1.0c	0.31 ± 0.19b

The subscript indices represent the doses expressed as μmol/kg. I: Indomethacin; A: Amphetamine. TU: Total number of ulcerations; LU: Large ulcerations (> 1 mm); UI: Ulcer index.

^aP < 0.05,

^bP < 0.01,

^cP < 0.05 vs groupI.