Noninvasive evaluation of hepatic fibrosis in children with infant hepatitis syndrome

Table 1 Etiology of IHS

Etiology	n	%
Cytomegalovirus hepatitis (CMVH)	18	43.90
CMVH + Glucose-6-phosphate dehydrogenase	3	7.32
CMVH + congenital choledochocele	2	4.88
CMVH + intrahepatic biliary atresia	1	2.44
CMVH + hemangioma	1	2.44
Glycogen storage disease	5	12.20
Infant Hepatitis Syndrome (undefined)	8	19.51
Congenital deformity of biliary tract (Extrahepatic biliary atresia)	1	2.44
Congenital choledochocele	1	2.44
Drug-induced hepatitis	1	2.44
Total	41	100.00

Table 2 Doppler sonograms in hepatic veins in patients with different fibrosis stage of IHS n (%)

Group	Patients (n)	HV0	HV1	HV2	Total
Control group	46	43 (93.50)	3 (6.50)	0 (0.00)	46 (100)
Mild group	12	2 (16.67)	10 (83.33)	0 (0.00)	12 (100)
Moderate group	12	1 (8.33)	10 (83.4)	1 (8.33)	12 (100)
Severe group	15	1 (6.67)	10 (66.67)	4 (26.67)	15 (100)

Chi-square test, χ² = 37.67, P < 0.001.

Table 3 Serum fibrosis indexes in patients with different fibrosis stage of IHS (mean ± SD, μg/L)

Group	Patients (n)	HA	PC- III	C IV	LN
Control group	46	225.18 ± 80.58	432.32 ± 166.68	129.69 ± 33.08	141.63 ± 34.63
Mild group	12	352.11 ± 157.33a	445.73 ± 191.11	149.85 ± 49.27	151.22 ± 36.57
Moderate group	12	447.48 ± 175.57b	480.77 ± 217.15	141.91 ± 47.51	132.56 ± 41.29
Severe group	15	745.32 ± 231.12bd	580.36 ± 147.79 a	185.00 ± 45.82b	167.90 ± 29.41a

HA, Serum hyaluronic acid; PC- III: Pre-Collagen type III; C-IV: Collagen type IV; LN: Laminin.

^aP < 0.05, and

^bP < 0.01 vs control group;

^dP < 0.01, vs mild and moderate group.