Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats

doi:10.3748/wjg.v12.i41.6639

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Nov 7, 2006 (publication date) through Jul 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2006; 12(41): 6639-6645
Published online Nov 7, 2006. doi: 10.3748/wjg.v12.i41.6639

Table 1 General characteristics of rats

Characteristics	Sham		BDL		P
	Placebo n = 9	V-PYRRO/NO n = 12	Placebo n = 12	V-PYRRO/NO n = 10
Initial body weight (g)	299 ± 34	274 ± 29	288 ± 56	293 ± 67	NS
Body weight gain (%)	33 ± 21	22 ± 9	14 ± 12^a	21 ± 17	0.04
Liver / body weight (%)	2.3 ± 0.4	2.8 ± 0.3	5.9 ± 1.5^a	5.6 ± 2.0^c	< 0.0001
Ascites score	0	0	0.3 ± 0.9	0	NS

^aP < 0.05 vs sham,

^cP < 0.05 vs V-PYRRO/NO sham; NS: Not significant.

Table 2 Liver and kidney serum function tests of rats

Parameter	Sham		BDL		P
	Placebo n = 9	V-PYRRO/NO n = 12	Placebo n = 12	V-PYRRO/NO n = 10
Urea (mmol/L)	10.2 ± 2.1	7.9 ± 1.7	9.2 ± 1.6	9.5 ± 2.7	NS
Creatinine (μmol/L)	77 ± 25	63 ± 24	66 ± 11	73 ± 18	NS
AST (UI/L)	172 ± 52	123 ± 60	1150 ± 1480^a	1164 ± 1349^c	< 0.0001
ALT (UI/L)	48 ± 18	55 ± 36	88 ± 47	82 ± 20	NS
Alkaline phosphatases (UI/L)	160 ± 103	148 ± 80	380 ± 197^a	367 ± 141^c	< 0.001
Bilirubin (μmol/L)	1.0 ± 0.0	1.3 ± 0.5	117.0 ± 22.0^a	101.0 ± 30.0^c	< 0.0001

^aP < 0.05 vs sham placebo,

^cP < 0.05 vs sham V-PYRRO/NO; NS: Not significant.

Table 3 Hemodynamic data of rats

	Sham		BDL		P
	Placebo n = 9	V-PYRRO/NO n = 12	Placebo n = 12	V-PYRRO/NO n = 10
MAP (mm Hg)	119 ± 7	113 ± 11	104 ± 8^a	98 ± 13^b	< 0.001
Heart rate (beat/min)	441 ± 29	428 ± 44	411 ± 29	422 ± 26	NS
Cardiac index (mL/min .100 g)	14 ± 5	15 ± 4	39 ± 11^a	33 ± 6^a^c	< 0.0001
SVR (dyn.s.cm⁵.100 g¹.10³)	782 ± 355	636 ± 184	236 ± 89^a	248 ± 78^c	< 0.0001
Portal pressure (mmHg)	9.2 ± 0.8	8.0 ± 1.2	16.3 ± 2.2^a	11.9 ± 2.7^a^c^e	< 0.0001
SRS BF (mL/min)	0.22 ± 0.08	0.31 ± 0.12	1.33 ± 1.34^a	0.42 ± 0.22^e	0.007

^aP < 0.05 vs Sham,

^cP < 0.05 vs sham V-PYRRO/NO,

^eP < 0.05 vs BDL placebo. MAP: Mean arterial pressure, SRS BF: Spleno-renal shunt blood flow; SVR: Systemic vascular resistance; NS: Not significant.

Table 4 Liver fibrosis of rats

	Sham		BDL		P
	Placebo n = 9	V-PYRRO/NO n = 12	Placebo n = 12	V-PYRRO/NO n = 10
Area (%)	2.5 ± 0.5	3.1 ± 0.8	12.1 ± 4.3^a	8.4 ± 3.6^c^e	< 0.0001
Liver hydroxyproline (μg/g protein)	164 ± 26	171 ± 49	381 ± 88^a	268 ± 83^c^e	< 0.0001

^aP < 0.05 vs Sham,

^cP < 0.05 vs sham V-PYRRO/NO,

^eP < 0.05 vs BDL placebo.

Citation: Moal F, Veal N, Vuillemin E, Barrière E, Wang J, Fizanne L, Oberti F, Douay O, Gallois Y, Bonnefont-Rousselot D, Rousselet MC, Calès P. Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats. World J Gastroenterol 2006; 12(41): 6639-6645
URL: https://www.wjgnet.com/1007-9327/full/v12/i41/6639.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i41.6639