Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population

Table 1 The sex-age-adjusted ORs and 95% CIs of the iNOS C150T genotypes for gastric atrophy (GA) among H pylori seropositive controls

iNOS polymorphism	n	GA n (%)	OR	95% CI
C/C	217	121 (55.8)	1.00	Reference
C/T	30	16 (53.3)	0.90	0.42-1.94
T/T	3	0 (0)	0	-
C/T+T/T	33	16 (48.5)	0.75	0.36-1.56

Table 2 The sex-age-adjusted ORs and 95% CIs of the iNOS C150T genotypes for gastric cancer

iNOS polymorphism	Cases1n (%)(n = 201)	Controls n (%)(n = 454)	OR	95% CI
C/C	175 (87.1)	403 (88.8)	1.00	Reference
C/T	25 (12.4)	48 (10.6)	1.22	0.69-2.17
T/T	1 (0.50)	3 (0.66)	0.71	0.07-7.54
C/T + T/T	26 (12.9)	51 (11.2)	1.19	0.68-2.08

¹One case subject could not be genotyped.

Table 3 The distribution of the iNOS C150T genotype in case, considering the location of gastric cancer and the phenotype iNOS

Polymorphism	Phenotype1	Total cases2n (%)	OR	95% CI	Non-cardia n (%)	OR	95% CI	Cardia n (%)	OR	95%CI
		(n = 185)			(n = 177)			(n = 8)
C/C	Differentiated	93 (82.3)	1.00		86 (81.9)	1.00		7 (87.5)	1.00
C/T	Differentiated	20 (17.7)	2.02	1.04-3.92a	19 (18.1)	2.13	1.08-4.18a	1 (12.5)	1.28	0.15-11.0
T/T	Differentiated	0 (0)	0		0 (0)	0		0 (0)	0
C/T + T/T	Differentiated	20 (17.7)	1.84	0.96-3.54	19 (18.1)	1.94	1.00-3.78a	1 (12.5)	1.16	0.14-9.95
C/C	Undifferentiated	69 (95.8)	1.00		69 (95.8)	1.00		0	-
C/T	Undifferentiated	2 (2.78)	0.25	0.06-1.06	2 (2.78)	0.25	0.06-1.06	0	-
T/T	Undifferentiated	1 (1.39)	1.74	0.17-18.1	1 (1.39)	1.74	0.17-18.1	0	-
C/T + T/T	Undifferentiated	3 (4.17)	0.35	0.10-1.17	3 (4.17)	0.35	0.10-1.17	0	-

^aP < 0.05 vs control group.

¹Information on gastric cancer phenotype was not available for 16 cases;

²One case subject with undifferentiated type could not be genotyped.