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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2006; 12(39): 6280-6284
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6280
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6280
Table 1 Gastric endocrine tumor classification, WHO[6]
Classification | Diameter | Ki-67 PI1 | Mitosis | Extension |
Well differentiated endocrine tumor (carcinoid tumor) | ≤ 1 cm | ≤ 2% | ≤ 2/10 HPF2 | Mucosa- submucosa |
Well differentiated endocrine carcinoma (malignant carcinoid) | > 1 cm | > 2% | > 2/10 HPF2 | Muscularis propria and beyond |
Poorly differentiated endocrine carcinoma (small cell carcinoma) | Any diameter | > 15% | > 10/10 HPF2 | Vascular and neural invasion |
Table 2 Accompanying histopathologic features
Pathology | Patients (n) | Rate (%) |
Atrophy | 8 | 50.0 |
Neuroendocrine hyperplasia | 7 | 43.8 |
Intestinal metaplasia | 9 | 56.3 |
Neuroendocrine dysplasia | 3 | 18.8 |
Multifocality | 5 | 31.4 |
Submucosal extension | 8 | 50.0 |
Table 3 p21, p27, Ki-67 staining ratios (%)
Gene | Mean ± SD | Range |
p21 | 1.09 ± 1.44 | 0-4 |
p27 | 43.58 ± 31.27 | 10-95 |
Ki-67 | 0.7 ± 0.94 | 0-3 |
Table 4 p21 and p27 expressions and clinicopathologic features (%)
Clinicopathologicfeature | p21 | P3 | p27 | P3 | |
Gender | Male | 1.5 | 0.60 | 58.0 | 0.34 |
Female | 0.85 | 36.4 | |||
Localization | Fundus | 3.0 | < 0.05 | 90.5 | < 0.05 |
Other | 0.7 | 34.2 | |||
Multifocality | Multifocal | 0.7 | 0.57 | 45.7 | 0.92 |
Single focus | 1.25 | 42.9 | |||
NEH1 | Present | 1.0 | 0.842 | 50.8 | 0.64 |
Absent | 1.16 | 37.5 | |||
NED1 | Present | 0.7 | 0.57 | 45.7 | 0.80 |
Absent | 1.25 | 42.8 | |||
Atrophy | Atrophic | 1.3 | 0.47 | 46.4 | 0.50 |
Non-atrophic | 0.8 | 32.5 | |||
Intestinal metaplasia | IM2 (+) | χ4 | χ4 | 49.6 | 0.09 |
IM2 (-) | X4 | 16.5 | |||
Submucosal extension | Present | 1.0 | 0.893 | 49.3 | 0.67 |
Absent | 0.8 | 30.5 | |||
p27 immunoexpression | p21 expressing | χ4 | χ4 | 68.0 | < 0.05 |
p21 (-) | χ4 | 21.8 | |||
Follow-up | Recurrent | 0.0 | 0.094 | 26.7 | 0.51 |
Non-recurrent | 1.5 | 49.9 |
- Citation: Doganavsargil B, Sarsik B, Kirdok FS, Musoglu A, Tuncyurek M. p21 and p27 immunoexpression in gastric well differentiated endocrine tumors (ECL-cell carcinoids). World J Gastroenterol 2006; 12(39): 6280-6284
- URL: https://www.wjgnet.com/1007-9327/full/v12/i39/6280.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i39.6280