Comparison of different diagnostic methods in infants with Cholestasis

Table 1 Comparison of various diagnostic methods for INH and BA

			Final diagnosis
			BA (n= 19)		INH (n= 46)
Method	Patients (n)	Results	n	%	n	%	P 1
Clinical evaluation	65	BA INH	16 3	84.2 15.8	16 30	34.8 65.2	< 0.001
Liver enzymes	65	BA INH	13 6	68.4 31.6	26 20	56.5 43.5	0.373
Ultrasonography	65	BA INH	10 9	52.6 47.4	11 35	23.9 76.1	< 0.05
Hepatobiliary scintigraphy	65	BA INH	16 3	84.2 15.8	24 22	52.2 47.8	< 0.05
Liver biopsy	65	BA INH	19 0	100 0	2 44	4.3 95.7	< 0.001

¹BA vs INH, κ² analysis.

Table 2 Accuracy of various diagnostic methods for BA and INH

Diagnostic method	n1	BA (%)	n	INH (%)	n	INHvsBA (%)
Liver biopsy	19/19	100	44/46	95.2	63/65	96.9
Clinical evaluation	16/19	84.2	30/46	65.2	46/65	70.8
Ultrasonography	10/19	52.6	35/46	76.1	45/65	69.2
Hepatobiliary scintigraphy	16/19	84.2	22/46	47.8	38/65	58.5
Liver enzymes	13/19	68.4	20/46	43.5	33/65	50.8

¹Accurately diagnosed cases/performed cases.

Table 3 Sensitivity and specificity of various diagnostic methods for BA and INH

	Sensitivity for BA		Specificity for BA
Diagnostic method	%	n	%	n
Clinical evaluation	84.2	16/19	65.2	30/46
Liver enzymes	68.4	13/19	43.5	20/46
Ultrasonography	52.6	10/19	76.1	35/46
Hepatobiliary scintigraphy	84.2	16/19	47.8	22/46
Liver biopsy	100	19/19	95.7	44/46

Sensitivity for BA was equivalent to specificity for INH, and specificity for BA was identical to sensitivity for INH.

Table 4 Positive and negative predictive values of various diagnostic methods in BA and INH

	Positive PV forBA and negativePV for INH		Negative PV forBA and positivePV for INH
Diagnostic method	%	n	%	n
Clinical evaluation	50	16/32	90.9	30/33
Liver enzymes	33.3	13/39	76.9	20/26
Ultrasonography	47.6	10/21	79.5	35/44
Hepatobiliary scintigraphy	40	16/40	88	22/25
Liver biopsy	90.5	19/21	100	44/44

PV: Predictive value.