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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 28, 2006; 12(36): 5813-5819
Published online Sep 28, 2006. doi: 10.3748/wjg.v12.i36.5813
Published online Sep 28, 2006. doi: 10.3748/wjg.v12.i36.5813
Table 1 Anthropometry results before and after dietary intervention mean ± SD
Pre-diet (n = 10) | Post-diet (n = 10) | P | |
Weight (kg) | 96.3 (87.9-105.6) | 93.0 (83.9-103.0) | 0.006 |
BMI (kg/m2) | 31.3 (28.3-34.9) | 30.2 (27.2-33.9) | 0.006 |
Waist circumference (cm) | 114.6 (107.8-121.4) | 107.9 (101.6-114.3) | 0.001 |
Systolic BP (mmHg) | 133.4 (117.0-149.8) | 129.8 (121.3-138.2) | 0.62 |
Diastolic BP (mmHg) | 79.4 (76.5-82.3) | 77.6 (71.9-83.8) | 0.50 |
Pulse (bpm) | 67.3 (60.6-75.2) | 66.3 (55.3-79.9) | 0.60 |
Table 2 Whole body MRI before and after dietary manipulation (n = 10, geometric mean)
Adipose tissue (L) | Pre-diet | Post-diet | Change (%) | P (t-test) |
Total | 38.8 (32.1 to 46.9) | 35.1 (28.5 to 43.4) | -9.5 (-14.4 to -4.4) | 0.003 |
Subcutaneous | 25.3 (20.8 to 30.8) | 22.8 (18.1 to 28.7) | -9.9 (-15.5 to -3.9) | 0.006 |
Internal | 13.3 (10.6 to 16.7) | 12.1 (9.6 to 15.2) | -9.3 (-14.1 to -4.2) | 0.003 |
Sc abdominal | 7.6 (5.8 to 10.1) | 6.9 (5.1 to 9.3) | -10.2 (-18.6 to -0.9) | 0.04 |
Sc peripheral | 17.6 (14.9 to 20.8) | 15.9 (12.9 to 19.5) | -9.7 (-14.9 to -4.3) | 0.003 |
Intra-abdominal | 7.6 (5.7 to 10.0) | 6.7 (5.1 to 8.7) | -11.4 (-16.5 to -6.0) | 0.001 |
Non-abdominal internal | 5.7 (4.7 to 6.9) | 5.4 (4.4 to 6.6) | -5.4 (-14.4 to 4.5) | 0.24 |
Table 3 Serum biochemistry results before and after dietary manipulation (n = 10)
Biochemistry | Pre-diet | Post-diet | P |
Glucose (mmol/L) | 5.7 (5.2-6.2) | 5.5 (4.8-6.1) | 0.55 |
Insulin (mIU/L) | 13.4 (8.4-18.4) | 13.9 (8.2-19.5) | 0.82 |
HOMA %S | 424.04 (225.2-737.5) | 540.1 (38.0-1400.8) | 0.33 |
HOMA %B | 28.5 (17.5-43.4) | 25.2 (16.2-37.3) | 0.50 |
HbA1c | 6.0 (5.7-6.3) | 5.6 (5.2-6.1) | 0.03 |
Cholesterol (mmol/L) | 5.3 (4.6-6.1) | 5.0 (4.6-5.5) | 0.24 |
Total Chol:HDLc | 4.4 (3.7-5.4) | 4.0 (3.5-4.7) | 0.22 |
TG (mmol/L) | 1.9 (1.3-2.6) | 1.9 (1.4-2.4) | 0.88 |
AST (U/L) | 32.2 (26.5-37.9) | 28.4 (24.0-32.8) | 0.02 |
ALT (U/L) | 42.4 (29.1-55.7) | 36.6 (22.5-50.7) | 0.08 |
γGT (U/L) | 39.0 (18.0-60.0) | 40.2 (21.6-58.8) | 0.34 |
Table 4 Hepatic and Muscle fat before and after dietary modification (n = 10, geometric mean, t-test)
Table 5 Relationship between changes in liver biochemistry and adiposity
Change | Hepatic fat | AST | ALT | |||
r | P | r | P | r | P | |
Body weight | 0.74 | 0.01 | 0.16 | 0.7 | 0.32 | 0.4 |
Total AT | 0.70 | 0.02 | 0.42 | 0.22 | 0.49 | 0.15 |
Abdominal sc AT | 0.76 | 0.01 | 0.57 | 0.09 | 0.54 | 0.11 |
Peripheral sc AT | 0.45 | 0.2 | 0.15 | 0.7 | 0.17 | 0.6 |
Intra-abdominal AT | 0.83 | 0.003 | 0.71 | 0.02 | 0.83 | 0.003 |
Non-abdominal internal AT | 0.28 | 0.4 | 0.23 | 0.5 | 0.35 | 0.3 |
hepatic fat | - | - | 0.51 | 0.13 | 0.62 | 0.05 |
Soleus IMCL | 0.50 | 0.14 | 0.27 | 0.4 | 0.21 | 0.6 |
Tibialis IMCL | 0.53 | 0.12 | 0.42 | 0.22 | 0.56 | 0.09 |
- Citation: Thomas EL, Brynes AE, Hamilton G, Patel N, Spong A, Goldin RD, Frost G, Bell JD, Taylor-Robinson SD. Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. World J Gastroenterol 2006; 12(36): 5813-5819
- URL: https://www.wjgnet.com/1007-9327/full/v12/i36/5813.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i36.5813