Assessment of oxidative stress in chronic pancreatitis patients

Table 1 Main characteristics of patients with chronic pancreatitis and healthy controls

Characteristic	CP patients	Controls
n	35	35
Gender
Male/Female	17/18	18/17
Mean age (yr) (range)	51(25-74)	45 (27- 68)
Smoking
Yes/No	23/12	22/13

Table 2 Thiol plasma concentrations, FRAP antioxidant capacity, protein carbonyl plasma levels, TBARS plasma levels and ROS production in whole blood of patients with CP and controls mean (range)

Measure for oxidative stress	CP patients	Controls
Cys1 (μmol/L)	225 (124-314)a	249 (212-328)
Hcys2 (μmol/L)	13.6 (5.0-38.2)	12.7 (0.2-27.8)
CGS3 (μmol/L)	34.8 (23.5-124)a	39.3 (25.2-56.7)
GSH4 (μmol/L)	7.5 (2.4-18.5)a	8.9 (3.5-16.1)
FRAP5 (mmol Fe2+/L)	0.75 (0.31-1.73)a	0.99 (0.69-1.57)
Carbonyls (nmol/mg protein)	0.32 (0.02-1.47)a	0.04 (0.01-0.07)
TBARS6 (μmol/L)	4.98 (0.23-27.79)a	0.35 (0.04-0.68)
ROS7 production (RLU/104 cells)
PMA8-stimulated	40 (1-83)	33 (1-87)
STZ9-stimulated	124 (11-266)	111 (9-2130)

¹Cysteine;

²Homocysteine;

³Cysteinylglycine;

⁴Glutathione;

⁵Ferric reducing ability of plasma;

⁶Thiobarbituric acid-reactive substances; ⁷Reactive oxygen species;

⁸Phorbol 12-myritate 13-acetate;

⁹Serum treated zymosan.

^aP < 0.05 vs control.