Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs

Table 1 Serum concentrations at time of presentation with calcium carbimide or disulfiram induced liver damage

Patient	Bilirubinbin (mg/L)		ALT (U/L)	AP (× ULN)	Type of liver injury
	Total	Direct
1	22.4	14.4	553	× 3.4	Cholestatic hepatitis1
2	0.9	0.2	59	× 0.56	PAS-positive ground glass hepatitis1
3	11.8	8.43	713	× 1.4	Hepatocellular
4	27.1	16.72	1288	× 1.49	Septal fibrosis and active Chronic hepatitis1

¹ Liver biopsy findings. Abbreviations: ALT, alanine aminotransferase (n < 40 U/L); AP, alkaline phospaatase; ULN, upper limit of normality; total bilirubin (n < 1.2 mg/dL). The ALT and AP values are these at presentation where as bilirubin values are the hightest recorded.