Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas

Table 1 Comparison of clinicopathological data between EBV positive and EBV negative gastric carcinomas

	EBV positive gastric carcinomas (n = 25)	EBV negative gastric carcinomas (n = 103)	P value
Gender			NS
Male	20 (80%)	68 (66%)
Female	5 (20%)	35 (34%)
Age: range(mean)1	35-78 (60.5)	25-84 (61.2)	NS
Site of tumor			NS
Body and Cardia	8 (32%)	21 (20%)
Antrum	17 (68%)	82 (80%)
LN metastasis			NS
Absent	7 (28%)	43 (41%)
Present	18 (72%)	60 (59%)
Histological type			< 0.05
Diffuse	18 (72%)	41 (40%)
Intestinal	7 (28%)	62 (60%)
Lymphoid stroma			< 0.05
Minimal/mild	6 (24%)	71 (69%)
Moderate/intense	19 (76%)	32 (31%)

¹ Age in years; LN: Lymph node; NS: Not significant.

Table 2 Apoptosis related proteins expressions in EBV positive and EBV negative gastric carcinomas n (%)

	EBV positive gastric carcinoma (n = 25)	EBV negative gastric carcinoma (n = 103)	P value
P53			NS
Positive	11 (44)	55 (54)
Negative	14 (56)	48 (46)
Bcl-2			< 0.05
Positive	7 (28)	11 (11)
Negative	18 (72)	92 (89)
Bcl-x			NS
Positive	22 (88)	96 (93)
Negative	3 (12)	7 (7)
Bak			< 0.05
Positive	11 (44)	71 (69)
Negative	14 (56)	32 (31)
Bax			NS
Positive	24 (96)	88 (86)
Negative	1 (4)	15 (14)

Table 3 NOS expression in EBV positive and EBV negative gastric carcinomas n (%)

	EBV positive gastric carcinoma (n = 25)	EBV negative gastric carcinoma (n = 103)	P value
NOS1(nNOS)			< 0.05
Positive	23 (92)	69 (67)
Negative	2 (8)	34 (33)
NOS2 (iNOS)			NS
Positive	5 (20)	31(30)
Negative	20 (80)	72 (70)
NOS3 (eNOS)			< 0.05
Positive	18 (72)	36 (35)
Negative	7 (28)	67 (65)