Efficacy of mycofenolate mofetil for steroid-resistant acute rejection after living donor liver transplantation

Table 1 Target trough levels of calcineurin inhibitors and steroid dosage at Tokyo University

	Tacrolimus (ng/mL)	Cyclosporine (ng/mL)	Methylpredonisolone (mg/kg per day)
POD 1-7	15-20	300-350	20-0.75
POD 8-14	14-16	250-300	0.5-0.3
POD 15-90	10-15	200-250	0.3-0.12
POD 91-180	8-10	150-200	0.08-0.12
POD 180-	5-10	100-150	0.05

POD: Postoperative day.

Table 2 Outcome of patients with acute rejection stratified by the rescue treatment

Group	n	CMV antigenemian (%)	Systemic infection n (%)	Mortalityn (%)
Steriod	36	14 (39)	5 (14)	7 (19)
Steroid + MMF	44	18 (41)	4 (9)	2 (5)
OKT3	10	7 (70)	4 (40)	4 (40)
Total	90	39 (43)	13 (14)	13 (14)

CMV: Cytomegalovirus; MMF: Mycophenolate mofetil.