Host susceptibility to persistent hepatitis B virus infection

Table 1 Gene polymorphisms associated with clearance of HBV infection

Gene/loci	Population	Sample size	P value	Reference
HLA A 0301	Caucasian	563	0.0005	[30]
HLA -DRB1 1302	Caucasian	563	0.03	[30]
HLA-DRB1 1302	Gambian	638	0.012	[31]
HLA-DRB1 1101/1104	Chinese	190	0.0145	[32]
HLA-DQA1 0301	Chinese	190	0.0167	[32]
HLA-DR13	Korean	1272	< 0.001	[33]
TNF-alpha-238 GG genotype	Chinese	895	0.041	[34]
TNF-alpha-308 A	Korean	1400	< 0.001	[35]
TNF-alpha-857 TT genotype	Chinese	355	0.02	[36]
CTLA-4-1722 C			0.06	[37]
CTLA-4+49 G			0.02	[37]
CCR5 59029 G allele	Chinese	377	0.001	[38]

Table 2 Gene polymorphisms associated with susceptibility to chronic hepatitis B

Gene/loci	Population	Sample size	P value	Reference
HLA B 08	Caucasian	563	0.03	[30]
HLA B 44-Cw 1601	Caucasian	563	0.02	[30]
HLA B 44-Cw 0501	Caucasian	563	0.006	[30]
HLA-DRB1 0301	Chinese	190	0.0074	[32]
HLA-DRB1 1301/2				[39]
HLA-DR6	Korean	1272	< 0.001	[33]
HLA-DQA1 0501	Chinese	190	0.0157	[32]
HLA -DQA1 0501	African American	91	0.05	[40]
HLA -DQB1 0301	African American	91	0.01	[40]
HLA-DQB1 0301	Chinese	190	0.0075	[32]
TNF-alpha-863 A	Korean	1400		[35]
TNF-alpha-238 GG genotype	Chinese	355	0.02	[36]
TNF-alpha-238 GG genotype	Chinese	455	0.02	[41]
TNF-alpha-857 CC genotype	Chinese	895	< 0.001	[34]
IFN-gamma A/A genotype		77		[42]
CTLA-4+6230 A			0.04	[37]
CCR5 59029 A allelic genotype	Chinese	377	0.002	[38]
ESR1 29 T/T genotype	Chinese	2318	< 0.001	[43]

Table 3 Successful linkage analysis in infectious diseases

Diseases	Location of predisposing genes	Reference
H pylori	IFNGR1	[60]
Plasmodium falciparum	5q31-q33, MHC	[61-64]
Kala-azar	22q12, Imr2, Imr1	[65]
Tuberculosis	15q and Xq	[66]
Schistosoma mansoni	5q31-q33	[67]
Leprosy	10p13, 6q25	[68, 69]