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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2006; 12(27): 4359-4363
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4359
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4359
Table 1 Serum levels of TC, TG, HDL-C, LDL-C, FFA and the relative hepatic weight after treatment with osthole for 6 wk in alcohol-induced fatty liver rats (n = 10)
Group | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | FFA(μmol/L) | Relative hepatic weight (g/100 g) |
Control | 2.14 ± 0.28 | 0.40 ± 0.11 | 1.16 ± 0.16 | 0.80 ± 0.21 | 429.93 ± 90.28 | 2.36 ± 0.33 |
Model | 2.52 ± 0.30a | 0.51 ± 0.09a | 0.96 ± 0.24a | 1.32 ± 0.51b | 535.04 ± 105.44a | 2.82 ± 0.28b |
Osthole 5 mg/kg | 1.72 ± 0.18d | 0.38 ± 0.08d | 0.91 ± 0.30 | 0.64 ± 0.34d | 477.37 ± 109.47 | 2.30 ± 0.14d |
Osthole 10 mg/kg | 1.69 ± 0.29d | 0.36 ± 0.11d | 1.02 ± 0.17 | 0.50 ± 0.17d | 473.79 ± 196.55 | 2.30 ± 0.12d |
Osthole 20 mg/kg | 1.60 ± 0.36d | 0.37 ± 0.06d | 1.05 ± 0.15 | 0.43 ± 0.21d | 487.59 ± 130.79 | 2.37 ± 0.19d |
Lipanthyl 20 mg/kg | 1.82 ± 0.28d | 0.42 ± 0.09c | 1.01 ± 0.20 | 0.62 ± 0.31d | 654.74 ± 136.86c | 3.45 ± 0.18d |
Table 2 Levels of TC, TG, SOD, MDA and GSH-PX in liver after treatment with osthole for 6 wk in alcohol-induced fatty liver rats (n = 10)
Group | TC (mg/g wet tissue) | TG (mg/g wet tissue) | SOD (U/mg prot) | MDA (nmol/mg prot) | GSH-PX (vigor units) |
Control | 1.94 ± 0.24 | 15.27 ± 3.35 | 58.33 ± 4.28 | 4.14 ± 1.34 | 174.86 ± 49.56 |
Model | 2.25 ± 0.36a | 18.88 ± 3.81a | 50.04 ± 8.20a | 5.36 ± 0.82a | 206.80 ± 66.07 |
Osthole 5 mg/kg | 1.82 ± 0.38d | 16.19 ± 4.21 | 61.11 ± 3.26d | 3.90 ± 1.35d | 203.80 ± 41.24 |
Osthole 10 mg/kg | 1.80 ± 0.25d | 14.25 ± 3.10d | 61.45 ± 3.62d | 3.74 ± 0.99d | 182.30 ± 31.42 |
Osthole 20 mg/kg | 1.76 ± 0.21d | 13.67 ± 4.30d | 58.91 ± 3.72d | 2.88 ± 0.92d | 171.89 ± 32.44 |
Lipanthyl 20 mg/kg | 1.61 ± 0.20d | 12.84 ± 3.22d | 53.80 ± 2.49 | 2.59 ± 0.54d | 200.95 ± 55.26 |
Table 3 Histopathological changes of hepatic fatty degeneration after treatment with osthole 5-20 mg/kg for 6 wk in alcohol-induced fatty liver rats (n = 10)
Degreeof fattydegeneration | Control | Model | Osthole | Lipanthyl20 mg/kg | ||
5 mg/kg | 10 mg/kg | 20 mg/kg | ||||
— | 9 | 0 | 2 | 2 | 4 | 6 |
+ | 1 | 5 | 7 | 8 | 6 | 4 |
++ | 0 | 5 | 1 | 0 | 0 | 0 |
+++ | 0 | 0 | 0 | 0 | 0 | 0 |
P | < 0.01 | < 0.05 | < 0.05 | < 0.01 | < 0.01 |
Table 4 Serum levels of TC, TG, HDL-C, LDL-C, FFA and the relative hepatic weight after treatment with osthole for 6 wk in high fat-induced fatty liver quails (n = 10)
Group | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | FFA(μmol/L) | Relative hepatic weight (g/100 g) |
Control | 5.74 ± 0.51 | 0.68 ± 0.14 | 5.12 ± 0.48 | 0.31 ± 0.23 | 963.21 ± 231.70 | 1.89 ± 0.16 |
Model | 9.53 ± 3.92b | 0.89 ± 0.21a | 5.35 ± 0.98 | 3.78 ± 3.36b | 1303.77 ± 372.58a | 2.13 ± 0.19b |
Osthole 5 mg/kg | 7.34 ± 0.88 | 0.49 ± 0.08d | 5.50 ± 0.58 | 1.62 ± 0.73 | 938.68 ± 146.77d | 1.83 ± 0.11d |
Osthole 10 mg/kg | 7.32 ± 1.53 | 0.57 ± 0.16d | 5.56 ± 0.93 | 1.50 ± 1.41 | 794.34 ± 225.05d | 1.83 ± 0.25d |
Osthole 20 mg/kg | 6.89 ± 0.84c | 0.45 ± 0.05d | 5.72 ± 0.75 | 0.98 ± 1.19c | 783.96 ±1 04.05d | 1.78 ± 0.13d |
Lipanthyl 20 mg/kg | 6.74 ± 0.73c | 0.55 ± 0.10d | 5.87 ± 0.66 | 0.62 ± 0.53d | 1170.75 ± 425.34 | 1.76 ± 0.19d |
Table 5 Levels of TC, TG, FFA, SOD, MDA and GSH-PX in liver after treatment with osthole for 6 wk in high fat-induced fatty liver quails (n = 10)
Group | TC (mg/g wet tissue) | TG (mg/g wet tissue) | FFA (mg/g wet tissue) | SOD (U/mg prot) | MDA (nmol/mg prot) | GSH-PX (vigor units) |
Control | 2.26 ± 0.56 | 11.42 ± 4.37 | 499.14 ± 90.73 | 368.10 ± 21.60 | 10.93 ± 2.44 | 121.53 ± 20.88 |
Model | 6.94 ± 3.25b | 17.34 ± 5.90a | 418.97 ± 181.75 | 314.24 ± 17.91b | 11.37 ± 1.71 | 111.23 ± 29.85 |
Osthole 5 mg/kg | 4.32 ± 0.69c | 16.05 ± 4.74 | 508.62 ± 180.05 | 343.20 ± 33.71c | 10.73 ± 2.30 | 130.00 ± 38.82 |
Osthole 10 mg/kg | 4.05 ± 1.82c | 13.48 ± 2.55 | 478.45 ± 134.74 | 344.16 ± 10.25d | 10.86 ± 3.56 | 151.40 ± 41.34c |
Osthole 20 mg/kg | 3.66 ± 1.14d | 12.97 ± 2.38c | 419.83 ± 106.21 | 353.70 ± 33.95d | 10.73 ± 0.95 | 174.35 ± 46.43d |
Lipanthyl 20 mg/kg | 4.05 ± 1.06c | 14.87 ± 6.21 | 731.03 ± 237.13d | 357.98 ± 16.08d | 11.02 ± 1.90 | 150.05 ± 46.54c |
Table 6 Histopathological changes of hepatic fatty degeneration after treatment with osthole 5-20 mg/kg for 6 wk in high fat-induced fatty liver quails (n = 10)
Degreeof fattydegeneration | Control | Model | Osthole | Lipanthyl | ||
5 mg/kg | 10 mg/kg | 20 mg/kg | 20 mg/kg | |||
— | 10 | 0 | 3 | 4 | 7 | 5 |
+ | 0 | 4 | 7 | 6 | 3 | 4 |
++ | 0 | 4 | 0 | 0 | 0 | 1 |
+++ | 0 | 2 | 0 | 0 | 0 | 0 |
P | < 0.01 | < 0.01 | < 0.01 | < 0.01 | < 0.01 |
- Citation: Song F, Xie ML, Zhu LJ, Zhang KP, Xue J, Gu ZL. Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals. World J Gastroenterol 2006; 12(27): 4359-4363
- URL: https://www.wjgnet.com/1007-9327/full/v12/i27/4359.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i27.4359