Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals

doi:10.3748/wjg.v12.i27.4359

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2006; 12(27): 4359-4363
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4359

Table 1 Serum levels of TC, TG, HDL-C, LDL-C, FFA and the relative hepatic weight after treatment with osthole for 6 wk in alcohol-induced fatty liver rats (n = 10)

Group	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	FFA(μmol/L)	Relative hepatic weight (g/100 g)
Control	2.14 ± 0.28	0.40 ± 0.11	1.16 ± 0.16	0.80 ± 0.21	429.93 ± 90.28	2.36 ± 0.33
Model	2.52 ± 0.30^a	0.51 ± 0.09^a	0.96 ± 0.24^a	1.32 ± 0.51^b	535.04 ± 105.44^a	2.82 ± 0.28^b
Osthole 5 mg/kg	1.72 ± 0.18^d	0.38 ± 0.08^d	0.91 ± 0.30	0.64 ± 0.34^d	477.37 ± 109.47	2.30 ± 0.14^d
Osthole 10 mg/kg	1.69 ± 0.29^d	0.36 ± 0.11^d	1.02 ± 0.17	0.50 ± 0.17^d	473.79 ± 196.55	2.30 ± 0.12^d
Osthole 20 mg/kg	1.60 ± 0.36^d	0.37 ± 0.06^d	1.05 ± 0.15	0.43 ± 0.21^d	487.59 ± 130.79	2.37 ± 0.19^d
Lipanthyl 20 mg/kg	1.82 ± 0.28^d	0.42 ± 0.09^c	1.01 ± 0.20	0.62 ± 0.31^d	654.74 ± 136.86^c	3.45 ± 0.18^d

^aP < 0.05,

^bP < 0.01 vs control animal.

^cP < 0.05,

^dP < 0.01 vs model animal.

Table 2 Levels of TC, TG, SOD, MDA and GSH-PX in liver after treatment with osthole for 6 wk in alcohol-induced fatty liver rats (n = 10)

Group	TC (mg/g wet tissue)	TG (mg/g wet tissue)	SOD (U/mg prot)	MDA (nmol/mg prot)	GSH-PX (vigor units)
Control	1.94 ± 0.24	15.27 ± 3.35	58.33 ± 4.28	4.14 ± 1.34	174.86 ± 49.56
Model	2.25 ± 0.36^a	18.88 ± 3.81^a	50.04 ± 8.20^a	5.36 ± 0.82^a	206.80 ± 66.07
Osthole 5 mg/kg	1.82 ± 0.38^d	16.19 ± 4.21	61.11 ± 3.26^d	3.90 ± 1.35^d	203.80 ± 41.24
Osthole 10 mg/kg	1.80 ± 0.25^d	14.25 ± 3.10^d	61.45 ± 3.62^d	3.74 ± 0.99^d	182.30 ± 31.42
Osthole 20 mg/kg	1.76 ± 0.21^d	13.67 ± 4.30^d	58.91 ± 3.72^d	2.88 ± 0.92^d	171.89 ± 32.44
Lipanthyl 20 mg/kg	1.61 ± 0.20^d	12.84 ± 3.22^d	53.80 ± 2.49	2.59 ± 0.54^d	200.95 ± 55.26

^aP < 0.05, ^bP < 0.01 vs control animal. ^cP < 0.05,

^dP < 0.01 vs model animal.

Table 3 Histopathological changes of hepatic fatty degeneration after treatment with osthole 5-20 mg/kg for 6 wk in alcohol-induced fatty liver rats (n = 10)

Degreeof fattydegeneration	Control	Model	Osthole			Lipanthyl20 mg/kg
Degreeof fattydegeneration	Control	Model	5 mg/kg	10 mg/kg	20 mg/kg	Lipanthyl20 mg/kg
—	9	0	2	2	4	6
+	1	5	7	8	6	4
++	0	5	1	0	0	0
+++	0	0	0	0	0	0
P	< 0.01		< 0.05	< 0.05	< 0.01	< 0.01

P value for medicine-treated or control animal vs model animal.

Table 4 Serum levels of TC, TG, HDL-C, LDL-C, FFA and the relative hepatic weight after treatment with osthole for 6 wk in high fat-induced fatty liver quails (n = 10)

Group	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	FFA(μmol/L)	Relative hepatic weight (g/100 g)
Control	5.74 ± 0.51	0.68 ± 0.14	5.12 ± 0.48	0.31 ± 0.23	963.21 ± 231.70	1.89 ± 0.16
Model	9.53 ± 3.92^b	0.89 ± 0.21^a	5.35 ± 0.98	3.78 ± 3.36^b	1303.77 ± 372.58^a	2.13 ± 0.19^b
Osthole 5 mg/kg	7.34 ± 0.88	0.49 ± 0.08^d	5.50 ± 0.58	1.62 ± 0.73	938.68 ± 146.77^d	1.83 ± 0.11^d
Osthole 10 mg/kg	7.32 ± 1.53	0.57 ± 0.16^d	5.56 ± 0.93	1.50 ± 1.41	794.34 ± 225.05^d	1.83 ± 0.25^d
Osthole 20 mg/kg	6.89 ± 0.84^c	0.45 ± 0.05^d	5.72 ± 0.75	0.98 ± 1.19^c	783.96 ±1 04.05^d	1.78 ± 0.13^d
Lipanthyl 20 mg/kg	6.74 ± 0.73^c	0.55 ± 0.10^d	5.87 ± 0.66	0.62 ± 0.53^d	1170.75 ± 425.34	1.76 ± 0.19^d

^aP < 0.05,

^bP < 0.01 vs control animal.

^cP < 0.05,

^dP < 0.01 vs model animal.

Table 5 Levels of TC, TG, FFA, SOD, MDA and GSH-PX in liver after treatment with osthole for 6 wk in high fat-induced fatty liver quails (n = 10)

Group	TC (mg/g wet tissue)	TG (mg/g wet tissue)	FFA (mg/g wet tissue)	SOD (U/mg prot)	MDA (nmol/mg prot)	GSH-PX (vigor units)
Control	2.26 ± 0.56	11.42 ± 4.37	499.14 ± 90.73	368.10 ± 21.60	10.93 ± 2.44	121.53 ± 20.88
Model	6.94 ± 3.25^b	17.34 ± 5.90^a	418.97 ± 181.75	314.24 ± 17.91^b	11.37 ± 1.71	111.23 ± 29.85
Osthole 5 mg/kg	4.32 ± 0.69^c	16.05 ± 4.74	508.62 ± 180.05	343.20 ± 33.71^c	10.73 ± 2.30	130.00 ± 38.82
Osthole 10 mg/kg	4.05 ± 1.82^c	13.48 ± 2.55	478.45 ± 134.74	344.16 ± 10.25^d	10.86 ± 3.56	151.40 ± 41.34^c
Osthole 20 mg/kg	3.66 ± 1.14^d	12.97 ± 2.38^c	419.83 ± 106.21	353.70 ± 33.95^d	10.73 ± 0.95	174.35 ± 46.43^d
Lipanthyl 20 mg/kg	4.05 ± 1.06^c	14.87 ± 6.21	731.03 ± 237.13^d	357.98 ± 16.08^d	11.02 ± 1.90	150.05 ± 46.54^c

^cP < 0.05,

^dP < 0.01 for medicine-treated animal versus model animal.

Table 6 Histopathological changes of hepatic fatty degeneration after treatment with osthole 5-20 mg/kg for 6 wk in high fat-induced fatty liver quails (n = 10)

Degreeof fattydegeneration	Control	Model	Osthole			Lipanthyl
Degreeof fattydegeneration	Control	Model	5 mg/kg	10 mg/kg	20 mg/kg	20 mg/kg
—	10	0	3	4	7	5
+	0	4	7	6	3	4
++	0	4	0	0	0	1
+++	0	2	0	0	0	0
P	< 0.01		< 0.01	< 0.01	< 0.01	< 0.01

P value for medicine-treated or control animal vs model animal.

Citation: Song F, Xie ML, Zhu LJ, Zhang KP, Xue J, Gu ZL. Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals. World J Gastroenterol 2006; 12(27): 4359-4363
URL: https://www.wjgnet.com/1007-9327/full/v12/i27/4359.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i27.4359