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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2006; 12(26): 4246-4249
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4246
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4246
Clinicopatho- logical parameters | Case (n) | MSI positive rates (%) | LOH positive rates (%) | BRCA1 positive rates (%) | BRCA1 expression (PU Mean±S) |
Histology | 37 | 7 (18.92%) | 7 (18.92%) | 14 (37.84%) | 33.56 ± 2.23 |
Tubuladenoma | 30 | 6 (20.00%) | 6 (20.00%) | 12 (40.00%) | 32.87 ± 2.93 |
High | |||||
differentiation | 9 | 4 (44.44%) 1 (7.69%) | 1 (11.11%) | 7 (77.78%)a | 34.03 ± 1.79 |
Middle | |||||
differentiation | 13 | 1 (12 .50 %) | 1 (7.69%) | 4 (30.77%) | 33.49 ± 2.34 |
Low | |||||
differentiation | 8 | 1 (14.29%) | 4 (50.00%) | 1 (12.50%) | 33.58 ± 1.67 |
Mucoadenoma | 7 | 1 (14.29%) | 2 (28.57%) | 32.87 ± 2.59 | |
Lymph metastasis | |||||
No | 17 | 5 (29.41%) | 1 (5.88%) | 9 (52.94%) | 34.75 ± 1.78 |
Yes | 20 | 2 (10.00%) | 6 (30.00%) | 5 (25.00%) | 33.14 ± 2.14 |
TNM staging | |||||
Stage I + II | 19 | 6 (31.58%) | 1 (5.26%) | 11 (57.89%) | 33.88 ± 2.38 |
Stage III + IV | 18 | 1 (5.56%)a | 6 (33.33%)a | 3 (16.67%)a | 33.23 ± 2.34 |
Grouping | Cases | BRCA1 proteinpositive rates | BRCA1 expression(PU Mean±S) |
MSI positive group | 7 | 85.71% (6/7) | 34.05 ± 1.91 |
MSI negative group | 30 | 26.67% (8/30) a | 32.59 ± 2.23 |
LOH positive group | 7 | 28.57% (2/7) | 32.87 ± 2.35 |
LOH negative group | 30 | 40.00% (12/30) | 34.03 ± 2.66 |
- Citation: Chen XR, Zhang WZ, Lin XQ, Wang JW. Genetic instability of BRCA1 gene at locus D17S855 is related to clinicopathological behaviors of gastric cancer from Chinese population. World J Gastroenterol 2006; 12(26): 4246-4249
- URL: https://www.wjgnet.com/1007-9327/full/v12/i26/4246.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i26.4246