Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

Table 1 Patient characteristics

	n = 116	%
Mean age (yr)	61.3 (40-90)
Male	101	87.1
Female	15	12.9
WHO performance status (OMS)
0	32	27.6
1	70	60.3
2	14	12.1
Dysphagia (Atkinson score)
0	2	1.7
1	21	18.1
2	58	50
3	26	22.4
4	9	7.8
Weight loss ≥ 10% at CRT
Initiation	30	25.9
TNM
T 1-2	27	23.3
3-4	89	76.7
N 0	50	43.1
1	54	46.5
x	12	10.4
M 0	116	100
1	-	-
Esophageal location
Upper one-third	35	30.2
Middle one-third	53	45.7
Lower one third	28	24.1
Mean tumour length (cm)	4.9 (0-15)
Histopathology
Squamous cell carcinoma	116

Table 2 Significant treatment toxicities per patient (%)

	Grade 3 (%)	Grade 4 (%)
Haematological
Neutropenia	9	3
Anemia	11	-
Thrombopenia	1	1
Mucositis
Oral	4	-
Esophageal	16	-
Gastrointestinal
Nausea	12	-
Diarrhoea	4	-
Neuropathy	1	-
Alopecia	3	-

Table 3 Predictive factors of survival, univariate and multivariate analysis

	Univariate	Multivariate
	P	P	OR	IC95
Sex	0.507	-
Age < 70	0.745	-
WHO performance status < 2	0.01	0.046	0.52	0.28-0.99
Weight loss < 10%	0.053	0.034	0.53	0.29-0.95
Dysphagia	0.074	-
T	0.273	-
N	0.499	-
Tumour location	0.501	-
Tumour length < 6 cm	0.045	0.534	0.86	0.53-1.38
Complete response to CRT	< 0.001	< 0.000	0.21	0.13-0.36