Copyright
©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2006; 12(26): 4185-4190
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4185
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4185
Table 1 Patient characteristics
n = 116 | % | |
Mean age (yr) | 61.3 (40-90) | |
Male | 101 | 87.1 |
Female | 15 | 12.9 |
WHO performance status (OMS) | ||
0 | 32 | 27.6 |
1 | 70 | 60.3 |
2 | 14 | 12.1 |
Dysphagia (Atkinson score) | ||
0 | 2 | 1.7 |
1 | 21 | 18.1 |
2 | 58 | 50 |
3 | 26 | 22.4 |
4 | 9 | 7.8 |
Weight loss ≥ 10% at CRT | ||
Initiation | 30 | 25.9 |
TNM | ||
T 1-2 | 27 | 23.3 |
3-4 | 89 | 76.7 |
N 0 | 50 | 43.1 |
1 | 54 | 46.5 |
x | 12 | 10.4 |
M 0 | 116 | 100 |
1 | - | - |
Esophageal location | ||
Upper one-third | 35 | 30.2 |
Middle one-third | 53 | 45.7 |
Lower one third | 28 | 24.1 |
Mean tumour length (cm) | 4.9 (0-15) | |
Histopathology | ||
Squamous cell carcinoma | 116 |
Table 2 Significant treatment toxicities per patient (%)
Grade 3 (%) | Grade 4 (%) | |
Haematological | ||
Neutropenia | 9 | 3 |
Anemia | 11 | - |
Thrombopenia | 1 | 1 |
Mucositis | ||
Oral | 4 | - |
Esophageal | 16 | - |
Gastrointestinal | ||
Nausea | 12 | - |
Diarrhoea | 4 | - |
Neuropathy | 1 | - |
Alopecia | 3 | - |
Table 3 Predictive factors of survival, univariate and multivariate analysis
Univariate | Multivariate | |||
P | P | OR | IC95 | |
Sex | 0.507 | - | ||
Age < 70 | 0.745 | - | ||
WHO performance status < 2 | 0.01 | 0.046 | 0.52 | 0.28-0.99 |
Weight loss < 10% | 0.053 | 0.034 | 0.53 | 0.29-0.95 |
Dysphagia | 0.074 | - | ||
T | 0.273 | - | ||
N | 0.499 | - | ||
Tumour location | 0.501 | - | ||
Tumour length < 6 cm | 0.045 | 0.534 | 0.86 | 0.53-1.38 |
Complete response to CRT | < 0.001 | < 0.000 | 0.21 | 0.13-0.36 |
- Citation: Fiore FD, Lecleire S, Rigal O, Galais MP, Soussan EB, David I, Paillot B, Jacob JH, Michel P. Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma. World J Gastroenterol 2006; 12(26): 4185-4190
- URL: https://www.wjgnet.com/1007-9327/full/v12/i26/4185.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i26.4185