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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2006; 12(26): 4117-4129
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4117
Published online Jul 14, 2006. doi: 10.3748/wjg.v12.i26.4117
Mucosal growth factors and SBS | |||
Growth factor | Amino acids /MW | Main source | GI receptor localization |
GLP-2 | 33 aa/3.8 kDa | Ileal and colonic EE L-cells, pancreatic α cells | GLP-2R; EE cells, myenteric/submucosal neurons of ENS |
EGF | 53 aa/6.4 kDa | Submandibular gland, duodenal Brunner’s gland, epithelial and Paneth cells | EGFR/HER/ErbB, HER2/Neu/ErbB2, HER3/ErbB3, HER4/ErbB4 |
KGF (FGF-7) | 194 aa/2.5 kDa | Fibroblast-like stromal cells in epithelial tissue | KGFR; a/bFGFR epithelial cells |
Hb-EGF | 86 aa/22 kDa | Smooth muscle cells | Activate all as listed for the EGFR |
GH | 191 aa/22 kDa | Liver | CRF type-1, PRL-R |
TGF-α | 50-53 aa/6.2-6.4 kDa | Epithelial cells | Activate all as listed for the EGFR |
NT | 13 aa/? | Ileum/colon >> proximal SB, EE N-cells | NTR1 |
PYY | 36 aa/42 kDa | Ileal and colonic EE L-cells | Y1-R; EE cells, myenteric/submucosal neurons of ENS |
GRP | 14 aa/? | Neuroendocrine cells in the ENS, fibroblasts | GRPR antrum, upper GI tract |
CCK | 8, 33 aa/39 kDa | Duodenal EE I-cells | CCKA >> CCKB upper GI tissue |
myenteric/submucosal neurons of ENS | |||
Gastrin | 17 aa/21 kDa | Gastric antrum G-cells | CCKB >> CCKA |
34 aa/40 kDa | Pancreatic D-cells | upper GI tissue | |
IGF-I/II | I-70 aa/7.6 kDa, | Proximal SB >> distal, liver, | IGF-IR and IGF-IIR |
II-67 aa/7.4 kDa | Fibroblasts | epithelial cells, glial cells, fibroblasts |
- Citation: Martin G, Beck P, Sigalet D. Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation. World J Gastroenterol 2006; 12(26): 4117-4129
- URL: https://www.wjgnet.com/1007-9327/full/v12/i26/4117.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i26.4117