Predicting utility of a model for end stage liver disease in alcoholic liver disease

Table 1 Demographics and laboratory values

	N1	Range	Mean	Median	Std. deviation
Age	33	36.00-62.00	48.3939	49	7.7498
Yrs of drink	23	3.00-45.00	17.0000	15	10.3177
Alc g/d	22	50.00-360.00	157.7273	150	84.3565
DF	34	15.30-180.72	55.5650	42.25	38.0920
MELD	34	3.00-46.00	20.9118	19	8.5293
Hb	34	5.30-14.80	10.7088	10.85	2.3296
MCV	33	69.10-121.20	100.8606	102.3	11.6788
WBC	34	3000-27000	11300.0000	9340	6039.8068
PLT	34	31000-446000	171970.5882	150000	103840.6370
PT	34	13.10-40.00	20.0044	18.25	6.1619
INR	34	1.10-3.88	1.7415	1.6	0.5922
FIBR/GEN	30	50.00-1350.00	312.6700	289	237.3435
ALBUMIN	32	1.50-4.00	3.0500	3.05	0.4819
SGOT	34	33.00-970.00	164.4412	127.5	165.1286
SGPT	34	19.00-787.00	84.9706	46.5	132.8972
γGT	32	23.00-1967.00	534.7813	353.5	532.8706
ALP	32	65.00-561.00	196.4375	152.5	129.0354
TOTAL BIL	34	1.50-51.00	17.7841	14.73	13.5573
CREAT.	34	0.20-2.80	1.0353	0.95	0.5098
NH3	25	4.84-235.00	127.3936	1.5	60.5252
ESR	28	6.00-141.00	69.0357	72.5	41.7253
CRP	25	1.40-126.00	45.8164	38	40.0220

¹N = number of patients with known laboratory values, yrs: years, alc: alcohol consumption, Hb: hemoglobulin, WBC: white blood count, PLT: platelets, PT: prothrombin time, INR: international normalized ratio, SGOT: aspartate aminotransferase, SGPT: alanine aminotranferase, γGT: γ glutamyl transpeptidase, ALP: alkaline phosphatase, BIL: bilirubin, CREAT: creatinine, ESR: erythrocyte sentimentation rate, CRP: C-reactive protein, FIBR/GEN: fibrinogen.

Table 2 Univariate and multivariate logistic regression assessing 30 d and 90 d mortality

Univariate logistic regression		Variable	P value	Odds ratio	95.0%CI
30-d mortality		DF	0.033	1.051	1.004-1.101
		MELD	0.094	1.357	0.950-1.939
90-d mortality		DF	0.038	1.026	1.001-1.050
		MELD	0.046	1.132	1.002-1.278
		FS	0.048	0.059	0.004-0.979
		SGPT	0.057	7.199	0.944-54.931
		CRP (< 100)	0.910	0.001	0.000-53.00
		CRP (> 100)	0.067	14.000	0.83-235.080
Multivariate logistic regression
30-d mortality1	Step 1	DF	0.484	1.034	0.942-1.134
		MELD	0.707	1.120	0.621-2.021
	Step 2	DF	0.033	1.051	1.004-1.101
90-d mortality2	Step 5	DF	0.994	12.488	0.00-1.91+297
		MELD	0.997	0.129	0.000

¹30-d mortality: Variable(s) entered on step 1: DF, MELD, variable(s) entered on step 2: DF;

²90-d mortality: Variable(s) entered on step 1: DF, MELD, FS, SGPT, variable(s) entered on step 5: MELD. Only the statistically significant variables are documented.