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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 21, 2006; 12(23): 3722-3728
Published online Jun 21, 2006. doi: 10.3748/wjg.v12.i23.3722
Published online Jun 21, 2006. doi: 10.3748/wjg.v12.i23.3722
Table 1 Characteristics of patients with different response to IFN therapy
Sustained responders | Non-responders | P | |
Patients (n) | 16 | 69 | |
Age (yr) | 51.2 ± 10.7 | 52.4 ± 11.1 | NS |
Male/Female | 14/2 | 47/22 | NS |
History of blood | 5/11 | 21/48 | NS |
transfusion (+/-) | |||
ALT (IU/I) | 110.4 ± 88.0 | 95.6 ± 61.0 | NS |
Viral load (Meq/mL) | 0.9 ± 0.9 | 6.9 ± 7.8 | 0.0027 |
Histology | |||
Grade | 1.9 ± 0.7 | 2.3 ± 0.8 | NS |
Stage | 1.9 ± 0.7 | 2.5 ± 0.9 | 0.0154 |
Number of amino acid | |||
Substitutions in | |||
ISDR | 5.0 ± 1.2 | 0.7 ± 1.1 | < 0.0001 |
C-terminal part of E2 | 3.4 ± 1.7 | 2.5 ± 1.2 | 0.0149 |
N-terminal variable region | 1.6 ± 1.1 | 0.9 ± 0.9 | 0.0148 |
Substitution of aa 625 (+/-) | 6/10 | 8/61 | 0.0213 |
Table 2 Characteristics of patients with small or large viral load
Patients with small viral load | Patients with large viral load | P | |
Patients (n) | 24 | 61 | |
Age (yr) | 52.5 ± 11.0 | 52.0 ± 11.1 | NS |
Male/female | 19/5 | 42/19 | NS |
History of blood | |||
transfusion (+/-) | 8/16 | 18/43 | NS |
ALT (IU/I) | 89.3 ± 64.1 | 102.0 ± 67.6 | NS |
Viral load (Meq/mL) | 0.5 ± 0.1 | 7.8 ± 7.9 | 0.0001 |
Histology | |||
Grade | 2.2 ± 0.8 | 2.3 ± 0.8 | NS |
Stage | 2.3 ± 0.8 | 2.4 ± 0.9 | NS |
Number of amino acid | |||
Substitutions in | |||
ISDR | 3.3 ± 2.5 | 0.8 ± 1.2 | < 0.0001 |
C-terminal part of E2 | 3.1 ± 1.7 | 2.5 ± 1.2 | NS |
N-terminal variable region | 1.5 ± 1.0 | 0.9 ± 0.9 | 0.0090 |
Substitution of aa 625 (+/-) | 7/17 | 7/54 | NS |
- Citation: Ukai K, Ishigami M, Yoshioka K, Kawabe N, Katano Y, Hayashi K, Honda T, Yano M, Goto H. Mutations in carboxy-terminal part of E2 including PKR/eIF2α phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: Their correlation with response to interferon monotherapy and viral load. World J Gastroenterol 2006; 12(23): 3722-3728
- URL: https://www.wjgnet.com/1007-9327/full/v12/i23/3722.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i23.3722