Noni juice is not hepatotoxic

Table 1 Mean clinical laboratory values by week and dose groups

Parameter	Value	Placebo	30 mLTNJ	30 mL TNJ	750 mLTNJ
ALP (U/L)	Mean wk 0	61.67	58.65	54.00	54.44
	Mean wk 2	55.80	57.83	51.16	54.47
	Mean wk 4	63.56	59.48	54.99	53.07
	Mean wk 6	62.69	61.50	58.22	55.04
ALT (U/L)	Mean wk 0	17.80	18.00	17.88	21.98
	Mean wk 2	18.53	19.53	17.80	24.11
	Mean wk 4	18.99	20.10	17.75	22.71
	Mean wk 6	19.21	16.90	17.63	20.92
AST (U/L)	Mean wk 0	18.30	18.55	18.27	20.71
	Mean wk 2	18.04	19.67	19.18	22.32
	Mean wk 4	18.93	19.55	19.19	20.90
	Mean wk 6	18.42	18.95	18.64	19.87
Total bilirubin (μmol/L)	Mean wk 0	12.12	10.55	10.93	11.30
	Mean wk 2	13.19	11.31	11.47	14.20
	Mean wk 4	12.23	11.63	12.07	14.03
	Mean wk 6	14.77	11.99	11.44	13.98
GGT (U/L)	Mean wk 0	20.31	24.74	22.51	21.36
	Mean wk 2	21.19	26.74	23.03	20.99
	Mean wk 4	21.87	26.54	21.14	21.21
	Mean wk 6	21.11	24.22	20.00	21.07

Table 2 Serum values in female Sprague Dawley rats in 1st 13-wk study (Mean ± SD)

Females
Dose	ALT (μkat/L)	AST (μkat/L)	ALP (μkat/L)	BIL (μmol/L)	GGT (μkat/L)
Control	2.1 ± 0.5	2.26 ± 0.46	2.07 ± 0.27	1.21 ± 0.61	0.02 ± 0.01
0.4 mL/kg	1.89 ± 0.62	2.15 ± 0.81	2.22 ± 0.29	1.43 ± 0.52	0.01 ± 0.01
4 mL/kg	1.98 ± 0.34	1.99 ± 0.39	2.08 ± 0.41	1.36 ± 0.54	0.01 ± 0
8 mL/kg	1.94 ± 0.33	1.74 ± 0.18	2.3 ± 0.45	1.22 ± 0.63	0.01 ± 0

Table 3 Serum values in male Sprague Dawley rats in 1^st 13-wk study (Mean ± SD)

Males
Dose	ALT (µkat/L)	AST (µkat/L)	ALP (µkat/L)	BIL (µmol/L)	GGT (µkat/L)
Control	2.47 ± 0.42	2.11 ± 0.58	2.97 ± 0.33	1.59 ± 0.32	0.01 ± 0.01
0.4 mL/kg	2.27 ± 0.52	1.8 ± 0.56	2.82 ± 0.39	1.5 ± 0.41	0 ± 0
4 mL/kg	2.35 ± 0.44	1.86 ± 0.32	2.77 ± 0.36	1.5 ± 0.36	0 ± 0
8 mL/kg	2.4 ± 0.61	2.06 ± 0.76	3.18 ± 0.44	1.6 ± 0.49	0.01 ± 0

Table 4 Serum values in female Sprague Dawley rats in 2^nd 13-wk study (Mean ± SD)

Females
Dose	ALT (µkat/L)	AST (µkat/L)	ALP (µkat/L)	BIL (µmol/L)	GGT (µkat/L)
Control	2.01 ± 0.3	1.73 ± 0.43	2.24 ± 0.36	1.01 ± 0.77	0.01 ± 0.01
20 mL/kg	2.14 ± 0.52	1.99 ± 0.71	2.44 ± 0.47	1.17 ± 0.72	0.01 ± 0.01
50 mL/kg	1.91 ± 0.53	1.82 ± 0.43	2.14 ± 0.43	1.24 ± 0.58	0.01 ± 0.01
80 mL/kg	1.25 ± 0.25	1.22 ± 0.12	1.98 ± 0.22	1.62 ± 0.77	0.01 ± 0.01

Table 5 Serum values in male Sprague Dawley rats in 2^nd 13-wk study (Mean ± SD)

Males
Dose	ALT (µkat/L)	AST (µkat/L)	ALP (µkat/L)	BIL (µmol/L)	GGT (µkat/L)
Control	2 ± 0.26	1.83 ± 0.21	3.51 ± 0.42	1.23 ± 0.25	0 ± 0
20 mL/kg	1.95 ± 0.3	1.79 ± 0.31	3.09 ± 0.47	0.93 ± 0.56	0 ± 0
50 mL/kg	1.55 ± 0.2	1.53 ± 0.28	3.17 ± 0.38	1.27 ± 0.45	0 ± 0
80 mL/kg	1.67 ± 0.4	1.77 ± 0.47	3.27 ± 0.29	1.03 ± 0.45	0 ± 0