Inhibitory effect of angiotensin II receptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis

doi:10.3748/wjg.v12.i2.322

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Jan 14, 2006 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2006; 12(2): 322-326
Published online Jan 14, 2006. doi: 10.3748/wjg.v12.i2.322

Table 1 Characteristics and biochemical data of patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) before losartan treatment

Paremeters	NAFL (n = 8)	NASH (n = 7)
Age (yr) Male/female	59 (34-76) 4/4	59 (41-65) 2/5
BMI (kg/m²)	24.5 (21.4-31.4)	26.1 (22.6-36.7)
SBP (mmHg)	130 (92-156)	148 (127-171)
DBP (mmHg)	78 (54-96)	90 (71-100)
AST (IU/L)	54 (42-70)	84 (20-128)
ALT (IU/L)	72 (56-110)	132 (54-138)
γ-GTP (IU/L)	30 (17-43)	53 (42-127)^a
TC (mg/dL)	209 (169-254)	222 (160-319)
TG (mg/dL)	128 (86-198)	124 (65-295)
FBS (mg/dL)	95 (86-112)	109 (97-132)^a
Ferritin (ng/mL)	111 (30-264)	199 (54-379)
HA (ng/mL)	46.5 (10.0-78.3)	89.4 (12.3-197.0)
IV collagen (ng/mL)	2.7 (2.0-3.5)	5.2 (3.1-9.9)^a

Values are expressed as median (range).

^aP < 0.05 vs NAFL; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; AST: aspartate aminotransferase; ALT: alanine aminotransferase; γ-GTP: γ-glutamyl transpeptidase; TC: total cholesterol; TG: triglyceride; FBS: fasting blood glucose; HA: hyaluronic acid; IV collagen: type IV collagen 7S.

Citation: Yokohama S, Tokusashi Y, Nakamura K, Tamaki Y, Okamoto S, Okada M, Aso K, Hasegawa T, Aoshima M, Miyokawa N, Haneda M, Yoneda M. Inhibitory effect of angiotensin II receptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis. World J Gastroenterol 2006; 12(2): 322-326
URL: https://www.wjgnet.com/1007-9327/full/v12/i2/322.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i2.322