Iwasaki J, Sano Y, Fu KI, Machida A, Okuno T, Kuwamura H, Yoshino T, Mera K, Kato S, Ohtsu A, Yoshida S, Fujii T. Depressed-type (0-IIc) colorectal neoplasm in patients with family history of first-degree relatives with colorectal cancer: A cross-sectional study. World J Gastroenterol 2006; 12(19): 3082-3087 [PMID: 16718792 DOI: 10.3748/wjg.v12.i19.3082]
Corresponding Author of This Article
Yasushi Sano, MD, PhD, Division of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-city, Chiba 277-8577, Japan. ys_endoscopy@hotmail.com
Article-Type of This Article
Rapid Communication
Open-Access Policy of This Article
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World J Gastroenterol. May 21, 2006; 12(19): 3082-3087 Published online May 21, 2006. doi: 10.3748/wjg.v12.i19.3082
Table 1 Initial colonoscopic findings of the patients
Patients without neoplasm
579 (36.5%)
Patients with neoplasm
1007 (63.5%)
Patients with only early stage neoplasm/cancer
651 (41.0%)
Patients with only advanced cancer
206 (13.0%)
Patients with both early stage neoplasm/cancer and advanced cancer
150 (9.5%)
Table 2 Odds ratio (OR) for early stage colorectal neoplasm calculated by univariate and multivariate analyses
No. of early stage neoplasm
Univariate analysis
Multivariate analysis
(n = 801)
Crude OR
95%CI
P-value
Adjusted OR
95%CI
P-value
Gender
Female
230
1
1.66-2.51
<0.0001
1
1.64-2.50
< 0.0001
Male
571
2.04
2.03
Age (yr)
< 60
248
1
1.04-1.58
0.018
1
0.96-1.47
0.11
≥ 60
553
1.29
1.19
Familyhistory of FDR with CRC
No
701
1
1.25-2.46
0.001
1
1.31-2.61
0.000
Yes
100
1.76
1.85
Table 3 Odds ratio (OR) for non 0-IIc colorectal neoplasm calculated by univariate and multivariate analyses
No. of non 0-IIc lesions
Univariate analysis
Multivariate analysis
(n = 775)
Crude OR
95%CI
P-value
Adjusted OR
95%CI
P-value
Gender
Female
221
1
1.65-2.50
< 0.0001
1
1.63-2.49
< 0.0001
Male
554
2.03
2.02
Age (yr)
< 60
240
1
1.03-1.57
0.023
1
0.95-1.45
0.14
≥ 60
535
1.27
1.18
Family history of FDR with CRC
No
680
1
1.17-2.28
0.004
1
1.22-2.41
0.002
Yes
95
1.63
1.71
Table 4 Odds ratio (OR) for 0-IIc colorectal neoplasm calculated by univariate and multivariate analyses
No. of 0-IIc lesions
Univariate analysis
Multivariate analysis
(n = 63)
Crude OR
95%CI
P-value
Adjusted OR
95%CI
P-value
Gender
Female
17
1
0.91-2.83
0.09
1
0.92-2.90
0.08
Male
46
1.61
1.63
Age (yr)
< 60
20
1
0.64-1.89
0.73
1
0.61-1.82
0.86
≥ 60
43
1.1
1.05
Family history of FDR with CRC
No
49
1
1.46-5.04
0.004
1
1.49-5.16
0.003
Yes
14
2.72
2.78
Citation: Iwasaki J, Sano Y, Fu KI, Machida A, Okuno T, Kuwamura H, Yoshino T, Mera K, Kato S, Ohtsu A, Yoshida S, Fujii T. Depressed-type (0-IIc) colorectal neoplasm in patients with family history of first-degree relatives with colorectal cancer: A cross-sectional study. World J Gastroenterol 2006; 12(19): 3082-3087