Effects of ranitidine for exercise induced gastric mucosal changes and bleeding

Table 1 Gastrointestinal symptoms in runners (n = 24)

	None	Mild	Moderate	Severe	Percentage of symptomatic subjects (%)
Diarrhea	9	13	1	1	63
Abdominal pain	10	12	2		58
Epigstric discomfort	10	12	2		58
Epigastric pain	12	10	2		50
Nausea	14	8	2		42
Regurgitation	16	8			33
Vomiting	19	4	1		21

Table 2 Endoscopic findings and hemoccult test before and after treatment with ranitidine

Subject/Sex	Before treatment(n = 24)			After treatment(n = 16)
	Endoscopic findings	Hp status	OB	Endoscopic findings	OB
1/M	Alkaline reflux gastritis	-	＋	Procedure refused	-
	Erosive gastritis (upper body)
2/M	Esophagitis, LA class A	-	-	Erosive gastritis	-
	Alkaline reflux gastritis			(antrum and body)
	Erosive gastritis (fundus)
3/M	Esophagitis LA class A	-	＋	Normal finding	-
	Erosion with blood clot (antrum)
4/M	Esophagitis, LA class A	＋	＋	Alkaline reflux gastritis	＋
	Alkaline reflux gastritis
5/M	Erosive gastritis	＋	＋	Normal finding	-
	(fundus, body, antrum )
6/M	Esophagitis, LA class A	-	-	Procedure refused
	Alkaline reflux gastritis
7/M	Erosive gastritis	＋	-	Procedure refused
	(fundus, body)
8/M	Gastric ulcer, Erosion with blood clot (midbody)	-	＋	Normal finding	-
9/M	Erosive gastritis (fundus)	＋	-	Normal finding	-
10/M	Erosive gastritis (fundus)	＋	-	Erosive gastritis (body)	-
11/M	Esophagitis, LA class A	＋	-	Procedure refused
	Alkaline reflux gastritis
12/M	Erosive gastritis (body, antrum )	-	-	Procedure refused
	Duodenitis
13/M	Normal finding	-	-	Procedure not performed
14/M	Esophagitis, LA class A	＋	-	Procedure refused
15/M	Erosive gastritis (antrum )	-	-	Normal finding	-
16/M	Erosive gastritis (body, antrum )	-	-	Erosive gastritis (antrum )	-
17/M	Alkaline reflux gastritis, Erosive gastritis with blood clot (angle)	-	-	Alkaline reflux gastritis	-
18/F	Duodenitis	-	-	Normal finding	-
19/F	Esophagitis, LA class A	-	-	Alkaline reflux gastritis	-
	Alkaline reflux gastritis
	Erosive gastritis (antrum)
20/F	Erosion with blood clot (midbody)	-	＋	Normal finding	-
21/F	Esophagitis, LA class A	-	-	Esophagitis, LA class A	-
	Erosive gastritis (fundus)
22/F	Alkaline reflux gastritis	-	＋	Alkaline reflux gastritis	-
	Erosive gastritis (antrum)
23/F	Normal finding	＋	-	Procedure not performed
24/F	Erosive gastritis (antrum)	＋	-	Normal finding	-

M, male; F, female; Hp, Helicobacter pylori; OB, occult blood; +, positive; -, negative; LA, Los Angeles.