Evaluation of thermal water in patients with functional dyspepsia and irritable bowel syndrome accompanying constipation

Table 1 Main items included in the questionnaire

Anagraphic data

Blood pressur, heart rate

Occupation

Physical activity1

Disease duration

Main symptoms1

Admission to hospital (d)1

Missed work days1

Clinical relapse1

Drugs comsumption12

Igienic-dietary habit1

Personal opinions on therapy2

Reasons of Good opinions on therapy2

Side effects2

¹During past 12 mo;

²Evaluation after treatment.

Table 2 Patients enrolled and re-evaluated after the first and second cycles of thermal therapy with mineral water

Water Type	Pathology	1st yr	2nd yr	3rd yr
	Dyspepsia
Bicarbonate		1 667	966	110
Salse		1 282	979	30
Solfate		923	923	24
Total		3 872	2 868	164
	IBSc
Bicarbonate		1 471	861	59
Salse		1 181	701	19
Solfate		957	949	30
Total		3 609	2 511	108

Table 3 Dyspepsia-IBSc: relapse after two cycles of thermal therapy

	1 cycle (%)2	2 cycles (%)2
Admission to hospital1	5.6	2.0
Work lack2	3.4	2.2
Clinical relapse	29.6	21.9

¹ In previous 12 mo.

² On yearly working days.

Table 4 Subjective evaluation of dyspepsia and IBSc

Personal opinions on therapy (%)		Reasons of good opinion (%)
Excellen	42	Care	95.6
Good	41.8	Relax	68
Lean	1.2	Stay	55.8
Null	6.3	Climate	45.3
No comment	8.4

Table 5 Parameters of gastric emptyng rate (¹³C octanoic acid breath test) in dyspeptic patients before and after mineral water supplementation therapy (mean ± SD)

	Pre-treatment	Post-treatment	P
T1/2	131 ± 18	91 ± 12	< 0.001
T-lag	92 ± 11	53 ± 11	< 0.001

Table 6 Prevalence of gastrointestinal symptoms before and after mineral water supplementation therapy in dyspeptic patients

Symptomatology	T0 % (n/n)	T2 % (n/n)	P
Gastric fullness	86 (48/56)	25 (14/56)	< 0.0001
Epigastric pyrosis	52 (29/56)	30 (17/56)	< 0.05
Bloating	52 (29/56)	23 (13/56)	< 0.005
Epigastric pain	24 (12/56)	11 (6/56)	NS
Nausea	5 (3/56)	0.2 (1/56)	NS
Vomiting	0.2 (1/56)	0 (0/56)	NS
Overall	100 (56/56)	68 (38/56)	< 0.0001

Table 7 Oro-cecal transit time in IBC patients before and after mineral water based diet (mean ± SD)

	Pre treatament	Post treatament	P
Patients	120 ± 12	97 ± 8	< 0.001
Controls	85.5 ± 14	81 ± 8	NS
P	< 0.001	< 0.001

Table 8 Gastrointestinal symptoms before and after mineral water supplementation therapy in patients with IBS

Symptoms	T0 % (n/n)	T21 % (n/n)	P
Bloating	90 (9/10)	20 (2/10)	< 0.005
Abdominal Pain	40 (4/10)	20 (2/10)	NS
	T0 Media	T21 Media
Evacuation/wk (n)	1.7	3.3	< 0.001

T0: Basal time T21: After mineral water supplementation therapy NS: Not significant