Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis

doi:10.3748/wjg.v12.i16.2523

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Apr 28, 2006 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Apr 28, 2006; 12(16): 2523-2529
Published online Apr 28, 2006. doi: 10.3748/wjg.v12.i16.2523

Table 1 Analysis of costimulatory molecules expressed on PBMCs (mean ± SD)

	Control n = 25	AIH Patients n = 34	P value
CD80	41.3 % ± 7.04 %	32.7 % ± 23.5 %	0.008
CD86	1.15 % ± 1.19 %	0.78 % ± 0.75 %	0.04
CD152 CTLA-4	13.8 % ± 10.9 %	2.32 % ± 2.80 %	0.01

The P values calculated by a Mann-Whitney’s U-test are shown. Compared to the healthy controls, CD80+, CD86+ and CD152+ PBMC of the patients with AIH are shown to be significantly fewer.

Table 2 Analysis of CD86+ cells in liver infiltrating mononuclear cells

γ-globulin (g/dL)		ALT (U/L)	ANA	Histology	HAI	CD86 (%)	CS	Reactivity to CS
No. 1	2.1	34	× 40	CH (A0, F2)	9	44.0	On	Reactive
No. 2	1.1	55	× 8	CH (A0, F1)	3	43.5	On	Reactive
No. 3	1.6	44	× 20	CH (A2, F3)	13	27.5	On	NT
No. 4	2.0	151	× 160	CH (A3, F3)	16	42.2	Off	Reactive
No. 5	2.0	99	× 40	CH (A0, F1)	3	43.7	Off	NT
No. 6	2.0	105	× 40	CH (A2, F2)	3	33.8	Off	NT
No. 7	2.3	71	× 640	CH (A1, F1)	5	41.2	Off	NT
No. 8	2.4	18	× 320	CH (A1, F2)	2	34.0	Off	NT
No. 9	1.6	50	× 320	LC (A1, F4)	18	19.1	Off	NT
No. 10	2.7	84	× 1 280	CH (A2, F2)	14	11.1	Off	Non-reactive
No. 11	1.3	131	× 5 120	CH (A2, F2)	14	28.9	Off	Reactive
No. 12	2.4	93	× 640	CH (A2, F2)	12	40.0	Off	Reactive
No. 13	1.7	363	× 2 560	CH (A2, F2)	15	27.3	Off	Reactive
No. 14	1.4	123	× 40	CH (A1, F1)	2	5.	Off	Non-reactive
No. 15	1.4	50	× 20	LC (A3, F4)	18	25.7	Off	NT
No. 16	2.1	34	× 20	CH (A2, F2)	12	29.4	Off	NT
No. 17	2.3	65	× 40	LC (A2, F4)	20	24.1	Off	Reactive
No. 18	1.9	17	× 1 280	CH (A2, F3)	12	23.0	Off	Reactive
No. 19	1.2	45	(-)	Fatty liver	NT	11.8	Off	NT
No. 20	1.3	47	(-)	Fatty liver	NT	10.7	Off	NT

Comparison of the level of CD86+ LIMC and clinical data in patients with AIH (18 cases) and fatty liver (2 cases). LIMCs taken from the liver biopsy specimen of patients with AIH (18 cases) and 2 patients with fatty liver were stained with antibody against CD86 and analyzed by using flow cytometry. Three thousand events were acquired for each analysis. Patients with AIH showed high levels of CD86+ LIMC irrespective of the levels of γ-globulin, ALT, histological activity, and the presence or absence of the administration of corticosteroids (CS). Response to CS in patients with AIH was shown to be associated with the level of CD86+ LIMC. NT: not tested.

Citation: Kurokohchi K, Masaki T, Himoto T, Deguchi A, Nakai S, Morishita A, Yoneyama H, Kimura Y, Watanabe S, Kuriyama S. Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis. World J Gastroenterol 2006; 12(16): 2523-2529
URL: https://www.wjgnet.com/1007-9327/full/v12/i16/2523.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i16.2523