Molecularly defined adult-type hypolactasia in school-aged children with a previous history of cow’s milk allergy

Table 1 Milk consumption and abdominal symptoms in school-aged children with a history of cow’s milk allergy¹ and their controls

	Previous allergy1	Controls
Questionnaire completed	92% (n = 86)	97% (n =77)
Milk product consumption	80% (n = 69)	100%a (n = 77)
Milk consumption < 1 dL/d	36% (23/69)	16%b (12/77)
Low lactose content in diet	14% (10/69)	8% (6/77)
Abdominal symptoms: Flatulence	13% (11/86)	8% (6/77)
Loose stools	5% (4/86)	4% (3/77)
Skin prick test >3 mm to cow’s milk	22%2 (20/91)	0 (0/77)

¹milk challenge positive at a mean age of 7 mo;

^aP < 0.0001 vs milk consumption;

^bP < 0.02 vs milk product consumption.

Table 2 Milk consumption and abdominal symptoms in school-aged children genotyped for adult-type hypolactasia

	T/T1-13910	C/T1-13910	C/C2-13910
Total number of children
n = 172	n = 68	n = 77	n = 27
Milk products consumed	95%	95%	93%
(n = 163)	(54/62)	(67/74)	(25/27)
Drinks milk < 1 dL/day	22%	18%	44%a
(n = 146)	(12/54)	(12/67)	(11/25)
Low lactose content in the diet	7%	4%	36%b
(n = 146)	(4/54)	(3/67)	(9/25)
Skin prick test >3 mm to cow’s milk	13%5	11%5	12%3
(n = 168)	(9/67)	(8/75)	(3/26)

¹lactase persistence;

²defines adult-type hypolactasia;

^aP < 0.02 vs genotypes associated with lactase persistence (T/T-₁₃₉₁₀ plus C/T-₁₃₉₁₀);

^bP < 0.002 vs T/T-₁₃₉₁₀ genotype or C/T-₁₃₉₁₀ genotype;

³each of these prick positive children had a diagnosis of cow’s milk allergy at a mean age of seven mo[17].

Table 3 Abdominal symptoms during a one-week period in school-aged children genotyped for adult-type hypolactasia

	Total	T/T1-13910	C/T1-13910	C/C2-13910
Questionnaire completed	n = 163	n = 62	n = 74	n = 27
Abdominal symptoms	(n = 38)	15% (n = 9)	27% (n = 20)	33%a(n = 9)
Flatulence	(n = 17)	5% (n = 3)	12% (n = 9)	19%b(n = 5)
Periumibilical pain	(n = 10)	6.5% (n = 4)	5.4% (n = 4)	7.4%(n = 2)
Loose stools	(n = 7)	3.2% (n = 2)	5.4% (n = 4)	3.7%(n = 1)
Upper epigastric pain	(n = 7)	5% (n = 3)	4.0% (n =3)	3.7%(n = 1)
Constipation	(n = 5)	0	5.4% (n = 4)	3.7%(n = 1)
Dyspepsia	(n = 1)	0	1.4% (n = 1)	0

¹lactase persistence;

² defines adult-type hypolactasia;

^aP = 0.05,

^bP < 0.04 vs T/T-₁₃₉₁₀ genotype.

Table 4 Probable changes in milk consumption of families after receiving the results of genetic testing for adult-type hypolactasia in school-aged children

	T/T1-13910	C/T1-13910	C/C2-13910
Questionnaire completed	94% (62/68)	97% (74/77)	100% (27)
No change in milk consumption	89% (n = 54)	81% (n = 61)	59%3 (n = 16)
Less lactose containing milk	0	0	33% (n = 9)
More lactose containing milk	8% (n = 5)	11% (n = 8)	0
Not decided	5% (n = 3)	7% (n = 5)	7% (n = 2)

¹lactase persistence;

²defines adult-type hypolactasia;

³33% of the families consumed low lactose containing diet prior to genetic testing.