Acute myopathy associated with liver cirrhosis

Table 1 Clinical characteristics of patients with liver cirrhosis who developed acute myopathy

Clinical parameters	Number of cases (n=99)
Sex (M:F)	74:25 (2.96:1)
Age (yr) range	27 - 76
mean	51 ± 10
Etiology of LC
Alcohol	47
CVH (B)	41
CVH (C)	5
Wilson's disease	1
Idiopathic	5
Child-Pugh Class
A:B:C	3:33:63

LC, Liver cirrhosis; CVH, Chronic viral hepatitis.

Table 2 Predisposing factors of acute myopathy in patients with liver cirrhosis (n=99)

Predisposing factors	Number of cases (%)
Infection	46 (46.5)
Respiratory infection	17
Gastrointestinal infection	12
Genitourinary infection	8
Septic shock	5
Alcohol	8 (8.1)
Exercise or trauma	8 (8.1)
Transarterial embolization	4 (4.0)
Herb medicine	3 (3.0)
Dehydration	2 (2.0)
Gastrointestinal bleeding	1 (1.0)
Idiopathic	27 (27.3)

Table 3 Muscle enzymes in patients with liver cirrhosis and acute myopathy

	AST (IU/L)	CPK (IU/L)	LDH (IU/L)
Class A	925	6 820.7	1013
Class B	1 359.8	21 083.3	1 991.7
Class C	1 231.2	21 147.9	1 936.1
Total	1 264.8	20 693.2	1 926.7
Peak daya	5.1	5.4	6.2

^aThe intervals from symptom onset to peak levels.

Table 4 Clinical outcome of patients with liver cirrhosis and acute myopathy by Child-Pugh's classification (n=93)

	Child-Pugh class (%)
Outcome	A	B	C	Total
Recovery	3(100)	26(83.9)	35(59.3)	64(68.8)
Death	0(0)	5(16.1)	24(40.7)	29(31.2)
Total	3	31	59	93a

^aSix patients (2 with Child-Pugh B and 4 with C) were lost to follow-up.