Correlation of Epstein-Barr virus and its encoded proteins with Helicobacter pylori and expression of c-met and c-myc in gastric carcinoma

Table 1 H pylori status in relation to clinicopathologic characteristics

	n	H pylori (+)	H pylori (-)	P
Sex
Male	134	78	56	0.574 (χ2=0.315)
Female	51	32	19
Age (yr)
30-	11	6	5
40-	29	15	14
50-	41	23	18	0.779 (χ2=1.764)
60-	59	38	21
≥70	45	28	17
Histological subtype
LDAC1	125	75	50
MDAC2	49	29	20	0.986
WDAC3	7	4	3
Signet ring carcinoma	4	2	2
Tumor stage
I	27	16	11
II	98	57	41	0.975 (χ2=0.216)
III	41	25	16
IV	19	12	7
Lymph node metastasis
Present	130	79	51	0.577 (χ2=0.311)
Absent	55	31	24
Tumor location
Cardia5	23	8	15
Body6	47	23	24
Antrum	95	68	27	0.003 (χ2=13.817)
Multiple	14	8	6
Remanent carcinoma4	6	3	3

¹LDAC: Lowly-differentiated adenocarcinoma;

²MDAC: Moderately-differentiated adenocarcinoma; WDAC: Well-differentiated adenocarcinoma;

⁴6 cases of remanent gastric carcinoma were not statistically analyzed;

⁵Compared with antrum, q = 4.528, P = 0.005;

⁶Compared with antrum, q = 3.681, P = 0.010.

Table 2 EBV status in relation to clinicopathologic characteristics

	n	EBV (+)	EBV (-)	P
Sex
Male	134	13	121	0.047 (χ2=3.940)
Female	51	0	51
Age (yr)
30-	11	0	11
40-	29	3	26
50-	41	2	39	0.669
60-	59	6	53
≥70	45	2	43
Histological subtype
LDAC1	125	11	114
MDAC2	49	1	48	0.141
WDAC3	7	0	7
Signet ring carcinoma	4	1	3
Tumor stage
I	27	1	26
II	98	5	93	0.259
III	41	4	37
IV	19	3	16
Lymph node metastasis
Present	130	10	120	0.818 (χ2=0.053)
Absent	55	3	52
Tumor location
Cardia5	23	1	22
Body6	47	7	40
Antrum	95	3	92	0.064
Multiple	14	1	13
remanent carcinoma4	6	1	5

¹LDAC: Lowly-differentiated adenocarcinoma;

²MDAC: Moderately-differentiated adenocarcinoma; WDAC: Well-differentiated adenocarcinoma;

⁴6 cases of remanent gastric carcinoma were not statistically analyzed.

Table 3 Relationship between EBV and H pylori in gastric carcinoma

	EBV(+)	EBV( -)	Total
H pylori (+)	6	104	110
H pylori (- )	7	68	75
Total	13	172	185

χ² =1.02, P = 0.317, r = -0.075

Table 4 c-myc and c-met expression in EBVaGC and EBVnGC

	n	c-myc expression		c-met expression		c-met overexpression
		+	-	+	-	+	-
EBVaGC	13	8	5	10	3	9	4
EBVnGC	45	25	20	29	16	17	28
χ2		0.147		0.259		4.035
P value		0.701		0.611		0.045