Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis

doi:10.3748/wjg.v12.i10.1607

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Mar 14, 2006; 12(10): 1607-1612
Published online Mar 14, 2006. doi: 10.3748/wjg.v12.i10.1607

Table 1 Laboratory characteristics of patients investigated according to the stage of disease¹

Stage	I	II	III	IV
Patients (n°)	12	11	15	13
Alkaline phosphatase (U/L	273 (50-797)	447 (145-1315)	397 (190-1956)	289 (52-1960)
AST (U/L)	28 (13-6)	38 (25-400)	35 (14-63)	49 (11-144)
ALT (U/L)	37 (14-89)	54 (17-100)	39 (17-72)	47 (8-218)
Total Bilirubin (mg/dL)	0.7 (0.4-2.4)	0.9 (0.2-1.2)	0.9 (0.3-1.5)	1.0 (0.5-1.6)
Cholesterol (mg/dL)	190 (112-235)	220 (104-285)	219 (110-275)	208 (154-314)
aPTT (sec)	32 (27-63)	28 (26-43)	32 (25-37)	32 (26-36)
PT (%)	98 (90-105)	100 (91-120)	99 (81-100)	93 (58-100)
Fibrinogen (mg/dL)	379 (279-650)	380 (268-463)	327 (276-590)	380 (100-586)

¹Data are expressed as median (range).

Table 2 Platelet and blood coagulation tests

	PBC patients n = 51	Controls n = 102
Sonoclot RATE (U/min) all pts	29 (14-49)^b	21 (14-31)
• <150 x 10³/μL plts (n = 22)	30 (14-49)^b
•≥150 x 10³/μL plts (n = 29)	28 (19-41)^d
Sonoclot TP (min) all pts	12 (6-30)^d	9 (6-15)
• <150 x 10³/μL plts (n = 22)	15 (6-30)^d
•≥150 x 10³/μL plts (n = 29)	10 (6-24)
PFA/EPI - CT (secs)	151.5 (60-222)	146 (111-179)
[≥150 x 10³/μL plts (n = 29)]
PFA/ADP- CT (secs)	106 (61-180)	102 (61-148)
[≥150 x 10³/μL plts (n = 29)]
TAT (μg/L)	2.8 (1.5-87.3)^b	2.5 (1.1-4.2)
D-Dimer (ng/mL)	16.0 (2-173)	23.0 (3-55)
TF (pg/mL)	255.6 (24.8-466.1)^d	121.9 (24.8-466.1)
TM (μg/mL)	23.7 (2.6-153.5)^d	13.8 (7.6-23.1)

^bP < 0.01,

^dP < 0.001 vs Controls; TP = time to peak; PFA/EPI - CT = closure time with epinephrine; PFA/ADP-CT = closure time with ADP. Data are expressed as median (range).

Table 3 Homocysteine and vitamin levels in PBC patients and controls

	PBC Patients (n = 51)	Controls (n =102)
Fasting HCY (μmol/L)	12.1 (1.8-58.8)^b	9.9 (6.4-18.0)
Post-methionine HCY (μmol/L)	30.1 (9.2-99.6)^b	28.0(16.4-38.9)
Folic Acid (ng/mL)	5.3(1.2-13.4)^b	10.7(5.4-18.5)
Vitamin B12 (pg/mL	335 (201-977)^a	304.9(176-427.1)
Vitamin B6 (pg/mL)	6.6 (1-20)^b	10.0 (3-17)

^aP < 0.05 vs controls;

^bP < 0.001 vs control.

Table 4 TTMTHFR polymorphism and vitamin state in 51 PBC patients n (%)

MMTHFR	Low folate,normal HCY	Normal folate,high HCY	Low folate,high HCY	Normal folate,normal HCY	Total Nopatients
CT	8 (38)	0	10 (47.6)	3 (14.45)	21
CC	8 (57)	0	2 (14.5)	4 (28.5)	14
TT	3 (18.7)	2 (12.5)	9 (56)	2 (12.5)	16
Total	19	2	21	9

Citation: Biagini MR, Tozzi A, Marcucci R, Paniccia R, Fedi S, Milani S, Galli A, Ceni E, Capanni M, Manta R, Abbate R, Surrenti C. Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis. World J Gastroenterol 2006; 12(10): 1607-1612
URL: https://www.wjgnet.com/1007-9327/full/v12/i10/1607.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i10.1607