Capsule 13C-urea breath test for the diagnosis of Helicobacter pylori infection

doi:10.3748/wjg.v11.i9.1361

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Mar 7, 2005 (publication date) through Jan 13, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2005; 11(9): 1361-1364
Published online Mar 7, 2005. doi: 10.3748/wjg.v11.i9.1361

Table 1 Comparison of data from 100- and 50-mg capsule UBT at different time points.

Method	2 min	4 min	6 min	8 min	10 min	15 min	20 min	25 min	30min
100-mg H pylori (+)	4.15 (5.33)^b	9.8 (11.02)^b	13.29 (11.73)^b	16.82 (14.03)^b	19.37 (15.55)^b	22.13 (14.89)^a^b	23.57 (17.63)^a^b	20.63 (15.23)^a^b	20.07 (15.29)^a^b
UBT H pylori (-)	0.39 (1.08)	0.32 (0.58)	0.45 (1.66)	0.29 (1.32)	0.48 (1.42)	0.31 (1.05)	0.42 (1.08)	0.35 (0.87)	0.53 (0.9)
50-mg H pylori (+)	1.8 (1.81)^b	6.63 (5.39)^b	9.95 (7.01)^b	11.68(7.48)^b	12.17(7.59)^b	12.79(7.29)^b	13.17 (8)^b	12.56 (8.02)^b	11.62 (6.75)^b
UBT H pylori (-)	0.04 (0.33)	0.04 (0.29)	0.04 (0.31)	-0.01 (0.33)	0.01 (0.31)	-0.08 (0.35)	0.1 (0.46)	0.02 (0.39)	0.02 (0.42)

Values are in excess δ¹³CO₂ excretion‰: mean±SD.

^aP<0.05 (100-mg UBT H pylori (+) vs 50-mg UBT H pylori (+)),

^bP<0.01 (H pylori (+) vs H pylori (-)).

Table 2 Sensitivity, specificity and accuracy of tests for the diagnosis of H pylori infection in patients with 100-mg capsule UBT.

	Sensitivity (%)	Specificity (%)	Accuracy (%)
CLO test (n = 50)	94.4 (17/18)	96.6 (31/32)	96 (48/50)
Histology (n = 50)	88.9 (16/18)	90.6 (29/32)	90 (45/50)
Culture (n = 50)	94.4 (17/18)	100 (32/32)	98 (49/50)
100-mg UBT (n = 50)	100 (18/18)	100 (32/32)	100 (50/50)

Table 3 Sensitivity, specificity and accuracy of tests for the diagnosis of H pylori infection in patients with 50-mg capsule UBT.

	Sensitivity (%)	Specificity (%)	Accuracy (%)
CLO test (n = 50)	82.1 (23/28)	95.5 (21/22)	88 (44/50)
Histology (n = 50)	92.9 (26/28)	90.9 (20/22)	92 (46/50)
Culture (n = 50)	64.2 (18/28)^b	100 (22/22)	80 (40/50)^b
50-mg UBT (n = 50)	96.4 (27/28)	100 (22/22)	98 (49/50)

^bP<0.01 vs UBT.

Table 4 Sensitivity, specificity and accuracy of tests for the diagnosis of H pylori infection in patients with 50- or 100-mg capsule UBT.

	Sensitivity (%)	Specificity (%)	Accuracy (%)
CLO test (n = 100)	87 (40/46)	96.3 (52/54)	92 (92/100)^a
Histology (n = 100)	91.3 (42/46)	90.7 (49/54)¹	91 (91/100)^a
Culture (n = 100)	76.1 (35/46)^b	100 (54/54)	89 (89/100)^b
UBT (n = 100)	97.8 (45/46)	100 (54/54)	99 (99/100)

^aP<0.05,

^bP<0.01,

¹P = 0.057 vs UBT.

Citation: Peng NJ, Lai KH, Liu RS, Lee SC, Tsay DG, Lo CC, Tseng HH, Huang WK, Lo GH, Hsu PI. Capsule ¹³C-urea breath test for the diagnosis of Helicobacter pylori infection. World J Gastroenterol 2005; 11(9): 1361-1364
URL: https://www.wjgnet.com/1007-9327/full/v11/i9/1361.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i9.1361