Hepatitis B virus infection and coronary atherosclerosis: Results from a population with relatively high prevalence of hepatitis B virus

Table 1 Traditional risk factors and CAD.

Characteristics	Frequency of factors%		P
	CAD (n = 291)	Non-CAD (n = 143)
Age (yr)	63.0510.46	59.4810.43	0.005
Male Sex	78.7	57.4	<0.0001
Smoking	42.6	18.9	<0.0001
Diabetes	19.6	7.8	0.001
Hypertension	72.5	57.3	0.002
Hypercholesterolemia	25.8	21.7	0.351
Family history	12.9	11.9	0.877
CRP (mg/L)	5.700.55	3.230.37	0.008

Table 2 Baseline characteristics of study population with or without HBV seropositivity.

Characteristics	HBV seropositive(n = 329)	Non-HBV seropositive(n = 105)	P
Age (yr)	62.12±10.06	62.49±11.18	0.29
Male (%)	70.2	73.3	0.622
Smoking (%)	32.8	40.9	0.158
Diabetes (%)	14.6	15.2	0.515
Hypertension (%)	62.3	64.8	0.812
Family history (%)	13.7	7.6	0.123
Hypercholesterolemia (%)	21.6	22.9	0.787

Table 3 Association between HBV serological markers and CRP level.

HBV serological markers	Pearson correlation (r)	P	P1
HBsAg	-0.036	0.511	0.406
Anti-HBs	-0.126	0.027	0.029
HbeAg2	0.000	1	1
Anti-HBe	-0.014	0.795	0.643
Anti-HBc	-0.115	0.049	0.032
HBV seropositive	-0.13	0.043	0.01

¹After adjustment for smoking.

²Fisher’s exact test was used.

Table 4 HBV serological markers and CAD.

HBV serum factor	Positive frequency of factors (%)		P
	CAD	Non-CAD
HbsAg	4.5	6.3	0.415
Anti-HBs	49.8	46.9	0.56
HbeAg	0.7	0	1
Anti-Hbe	22	21.7	0.969
Anti-HBc	69.4	59.4	0.066
Healthy carriers1	2.8	4.9	0.27
Resolved HBV infection2	11.7	9.1	0.474
HBsAg (-) HBV infection3	16.8	15.4	0.7
HBV seropositive	77	73.4	0.417

¹Healthy carriers: HBsAg (+), anti-HBc (+) and anti-HBeAg (+).

²Resolved HBV infection: anti-HBs (+), anti-HBc (+) and anti-HBe (+).

³HBsAg (-) HBV infection: anti-HBc positive only.