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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Feb 28, 2005; 11(8): 1122-1130
Published online Feb 28, 2005. doi: 10.3748/wjg.v11.i8.1122
Published online Feb 28, 2005. doi: 10.3748/wjg.v11.i8.1122
Table 1 Effect of TZD on apoptosis in pancreatic tumor cells. Extent of apoptosis following treatment of pancreatic cancer cell lines with 20 μmol/L of TZD (RGZ or PGZ) for three days was measured by the incorporation of FITC-dUTP in the presence of TdT enzyme to detect DNA fragmentation as described in Methods. Cells were stained with RNase A/PI and analyzed by flow cytometry. The mean±SD of five independent experiments each performed in triplicate are shown.
Treatment | Apoptosis (%) | |||
Panc-1 | Capan-2 | HPAC | P3-HPAC | |
Control (DMSO) | 1.16±0.15 | 0.88±014 | 0.46±0.19 | 0.66±017 |
RGZ | 1.20±0.17 | 0.90±0.22 | 0.38±0.17 | 0.58±0.19 |
PGZ | 1.19±0.14 | 0.93±0.17 | 0.40±0.18 | 0.57±0.13 |
- Citation: Ceni E, Mello T, Tarocchi M, Crabb DW, Caldini A, Invernizzi P, Surrenti C, Milani S, Galli A. Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells. World J Gastroenterol 2005; 11(8): 1122-1130
- URL: https://www.wjgnet.com/1007-9327/full/v11/i8/1122.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i8.1122