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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Feb 28, 2005; 11(8): 1115-1121
Published online Feb 28, 2005. doi: 10.3748/wjg.v11.i8.1115
Published online Feb 28, 2005. doi: 10.3748/wjg.v11.i8.1115
Table 1 Histological changes in the pancreas of rats with caerulein-induced acute pancreatitis (AP) in comparison to control group (C), SE range of scores in brackets.
No. | Group | Edema | PMNs infiltration | Necrosis | Vacuolization |
1 | Control (C) (n = 6) | (0-1) 0.12±0.03 | (0-1) 0.06±0.02 | (0) 0.00±0.00 | (0-1) 0.08±0.03 |
2 | Untreated AP (n = 10) | (1-3) 2.04±0.07b | (03) 1.61±0.08b | (0-2) 0.58±0.06b | (1-3) 1.88±0.08b |
3 | AP + LU 302872 10 mg/kg (n = 6) | (1-3) 2.02±0.07b | (1-3) 1.66±0.07b | (0-1) 0.48±0.05b | (1-3) 2.24±0.08bd |
4 | AP + LU 302872 20 mg/kg (n = 6) | (1-3) 2.30±0.06bdh | (0-3) 1.68±0.08b | (0-2) 0.50±0.05b | (1-3)2.41±0.07bd |
5 | AP + LU 302146 10 mg/kg (n = 6) | (0-3) 1.96±0.09b | (0-3) 1.43±0.09be | (0-2) 0.86±0.07bdf | (1-3)1.91±0.09bf |
6 | AP + LU 302146 20 mg/kg (n = 6) | (0-3) 2.14±0.07b | (0-3)1.41±0.07bce | (0-2) 0.82±0.06bdf | (1-3)2.19±0.07bdeg |
Table 2 Free active trypsin (FAT), total potential trypsin (TPT) activity and index of trypsinogen activation (%FAT/TPT) in whole homogenate of the rat pancreas in caerulein-induced acute pancreatitis (AP) in rats in comparison to control group (C) (mean±SE).
Group | FAT(mg/mg protein) | TPT (mg/mg protein) | FAT/TPT (%) |
Control (n = 6) | 0.394±0.094 | 8.90±1.14 | 4.8±1.3 |
Untreated AP (n = 10) | 1.542±0.249 | 9.77±0.94 | 18.4±3.8b |
AP+LU 302872 10 mg/kg (n = 6) | 1.543±0.134 | 10.56±1.04 | 14.9±1.2b |
AP+LU 302872 20 mg/kg (n = 6) | 1.245±0.176 | 9.06±2.18 | 16.7±2.6b |
AP+LU 302146 10 mg/kg (n = 6) | 0.969±0.08 | 6.61±0.98 | 16.0±2.6b |
AP+LU 302146 20 mg/kg (n = 6) | 1.869±0.52 | 8.11 ±1.55 | 21.8±3.0b |
- Citation: Andrzejewska A, Dlugosz JW, Augustynowicz A. Effect of endothelin-1 receptor antagonists on histological and ultrastructural changes in the pancreas and trypsinogen activation in the early course of caerulein-induced acute pancreatitis in rats. World J Gastroenterol 2005; 11(8): 1115-1121
- URL: https://www.wjgnet.com/1007-9327/full/v11/i8/1115.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i8.1115