Immunohistochemical assessment of angiogenesis in hepatocellular carcinoma and surrounding cirrhotic liver tissues

Table 1 Relationship between VEGF expression and clinicopathological Features of HCC (n=105).

Variables	Number of patients	VEGF expression		P
		Positive (n = 72)	Negative (n = 33)
Sex				NS
Male	79	54	25
Female	26	18	8	0.003
Age (yr)				NS
≤60	51	42	9
>60	54	30	24
Liver pathology
Cirrhosis	68	47	21
Hepatitis	37	25	12
Tumor size				NS
<5	71	47	24
≥5	34	25	9
Tumor differentiation				NS
High	27	18	9
Moderate	65	45	20
Poor	13	9	4
Capsule formation				NS
Presence	31	20	11
Absence	74	52	22
Capsule infiltration				0.005
Presence	65	51	14
Absence	40	21	19
Vascular invasion				0.035
Presence	34	28	6
Absence	71	44	27
Intrahepatic metastasis				0.008
Presence	23	21	2
Absence	82	51	31

NS: no significant difference.

Table 2 VEGF expression in HCC and surrounding cirrhotic liver tissues (n=68).

	VEGF expression		P
	Positive n (%)	Negative n (%)
HCC	47 (69.1)	21 (30.9)
Surrounding Cirrhotic liver	54 (79.4)	14 (20.6)	0.017