Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis

Table 1 Cardiorespiratory parameters.

	Cirrhosis	Controls	P
Mean arterial blood pressure (mmHg)	107±8.4	112±7.3	NS
Heart rate (bpm)	310±9.2	304±8.4	NS
paO2 (mmHg)	89.1±5.3	92.3±4.8	NS

Table 2 Microcirculatory parameters.

	CirrhosisCirrhosis	Controls	P
Vessel diameter (mm)
Liver	27.86±2.03	23.03±0.62	<0.01
Mesentery	32.06±8.91	33.46±11.66	NS
Mucosa	7.51±0.30	7.20±0.23	NS
Red blood cell velocity (mm/s)
Liver	0.93±0.09	1.22±0.18	<0.05
Mesentery	2.81±0.49	3.11±0.35	NS
Mucosa	2.03±0.15	2.18±0.16	NS
Volumetric blood flow (nL/min)
Liver	32.10±0.4	31.20±0.6	NS
Mesentery	135.10±3.5	156.50±4.3	<0.01
Mucosa	5.30±0.3	5.40±0.2	NS

Table 3 Leukocyte–endothelium interaction.

	Cirrhosis	Controls	P
Adherent leukocytes (n/100 mm)
Liver	1.91±0.28	0.50±0.5	<0.01
Mesentery	2.54±1.19	1.62±0.85	NS
Rolling leukocytes (n/100 mm)
Liver	4.80±0.90	2.33±0.75	<0.01
Mesentery	7.68±3.18	6.88±1.94	NS

Table 4 Blood tests.

	Cirrhosis	Controls	P
GOT (U/L)	63.67±10.42	28.67±4.85	<0.01
GPT (U/L)	31.83±4.84	16.67±1.11	<0.01
GGT (U/L)	5.33±1.49	3.17±0.69	<0.05
AP (U/L)	130.50±35.75	56.83±2.67	<0.01
Prothrombin time (%)	75.30±5.4	102.4±2.7	<0.01
Antithrombin III (IU)	108.50±14.59	125.0±8.96	<0.05