Role of PGI2 in the formation and maintenance of hyperdynamic circulatory state of portal hypertensive rats

Table 1 Effects of L-NNA and INDO on plasma PGI₂ and NO concentrations (mean±SD).

Group	Vehicle (n = 23)	L-NNA (n = 21)	Indo (n = 22)	Heparin (n = 24)
6-keto-PGF1α (pg/mL)
SO	725.53±105.54	748.48±67.68	336.91±37.05c	3965.96±976.82c
IHPH	1123.85±153.64a	494.74±145.98ac	342.86±104.79ac	2930.61±1400.38c
PHPH	891.88±83.11a	386.54±98.44ac	266.94±57.63c	2766.47±506.95c
NO2-/NO3- (μmol/L)
SO	58.79±8.47	21.31±1.76c	55.72±5.33	45.28±4.398c
IHPH	73.34±4.31a	40.17±10.32ac	46.42±7.43ac	54.02±11.89ac
PHPH	75.21±6.89a	30.45±3.28ac	54.74±4.39c	62.06±3.56ac

^aP<0.05 vs SO;

^cP<0.05 vs control.

Table 2 Effects of L-NNA and INDO on systemic hemodynamics (mean±SD).

Group	Vehicle (n = 23)	L-NNA (n = 21)	Indo (n = 22)	Heparin (n = 24)
MAP (mmHg)
SO	141.86±3.02	159.29±1.98c	145.86±3.72	157.33±3.77c
IHPH	134.00±1.83a	161.50±6.14c	161.14±4.45ac	137.88±2.17a
PHPH	130.29±1.89a	142.50±4.37ac	147.71±2.75c	138.29±4.39ac
CI (mL/min)
SO	28.46±0.58	25.34±2.22c	27.20±0.61	23.52±0.72c
IHPH	32.03±1.34a	25.03±1.76c	28.66±1.63c	28.39±2.25a
PHPH	33.19±0.66a	28.13±0.51ac	29.62±1.16ac	26.67±0.66ac
TPR (mmHg/mL·min)
SO	4.99±0.13	6.33±0.60c	5.36±0.13	6.70±0.33c
IHPH	4.19±0.18a	6.48±0.53c	5.64±0.42c	4.88±0.36a
PHPH	3.93±0.06a	5.07±0.19ac	5.00±0.33ac	5.18±0.21ac

^aP<0.05 vs SO;

^cP<0.05 vs control.

Table 3 Effects of L-NNA and INDO on systemic and splanchnic hemodynamics (mean±SD).

Group	Vehicle (n = 23)	L-NNA (n = 21)	Indo (n = 22)	Heparin (n = 24)
FPP (mmHg)
SO	6.93±0.35	7.29±0.39	7.07±0.35	7.06±0.39
IHPH	10.29±0.39a	8.75±0.46ac	9.28±0.57ac	9.25±0.65ac
PHPH	13.71±0.49a	10.05±0.45ac	11.57±0.53ac	11.07±0.79a
PVI (mL/min)
SO	2.35±0.27	1.06±0.20c	1.63±0.17c	1.57±0.31c
IHPH	3.83±0.64a	2.34±0.50ac	2.16±0.59c	2.05±0.62ac
PHPH	7.37±1.56a	3.71±0.53ac	3.77±0.81ac	2.35±0.25ac
SVR (mmHg/mL·min)
SO	58.06±6.95	96.18±13.71c	85.56±8.13c	99.36±20.26c
IHPH	32.96±5.09a	67.83±14.33ac	74.75±19.34c	68.51±22.26ac
PHPH	16.39±3.23a	36.21±5.21ac	37.52±8.10ac	54.85±6.71ac

^aP<0.05 vs SO;

^cP<0.05 vs control.

Table 4 Pearson partial correlations between PGI₂, NO levels and hemodynamic parameters.

Hemodynamic parameters	PGI2(deduction of the action of NO)		NO (deduction of the action of PGI2)
	R	P	R	P
CI	-0.0259	0.8218	0.552	0.0001
MAP	-0.1335	0.2436	-0.4572	0.0001
TPR	0.0122	0.9154	-0.6053	0.0001
FPP	0.2598	0.0216	0.4659	0.0001
PVI	0.1536	0.1794	0.3579	0.0013
PVR	-0.0523	0.6493	-0.228	0.0446
SVR	-0.1216	0.2889	-0.4325	0.0001