Hepato-cardiovascular response and its regulation

Table 1 Changes in MAP and PVP during PVO, intraportal injection of microspheres and re-PVO after microsphere injections in experiment 1 (mean±SE).

	Basal	PVO	Microsphere injection	Re-PVO
MAP (kPa)
Group 1	11.6±0.4	13.0±0.3a	8.8±0.4a	9.0±0.4c
Group 2	11.2±0.3	13.2±0.5a	8.5±0.3a	9.3±0.3c
Group 3	11.4±0.4	12.6±0.3a	11.5±3.9	12.4±0.3
PVP (kPa)
Group 1	4.1±0.3	13.0±0.3b	4.5±0.3a	8.4±0.3c
Group 2	4.5±0.2	13.2±0.4b	5.1±0.2a	9.2±0.2c
Group 3	4.2±0.2	12.6±0.3b	4.2±0.2	12.4±0.3

Group 1: 15 μm microspheres; group 2: 80 μm microspheres; group 3: saline control. MAP, mean arterial pressure; PVP, portal venous pressure; PVO, portal venous occlusion.

^aP<0.05;

^bP<0.01 vs Basal.

^cP<0.05 vs PVO.

Table 2 Changes in CVP, MAP, ABF and AR before and after intraportal injection of microspheres in experiment 2 (mean±SE).

	Pre-injection	Post-injection	Change (%)
CVP (kPa)
Group 1	0.43±0.07	0.39±0.06	-6.9±0.72
Group 2	0.40±0.08	0.38±0.59	-5.5±0.66
Group 3	0.34±0.06	0.35±0.08	1.3±0.22
MAP (kPa)
Group 1	12.7±0.4	7.9±0.4a	-38.1±1.9
Group 2	12.9±0.6	8.4±0.5a	-35.4±2.1
Group 3	12.9±0.4	13.1±0.4	1.5±0.2
ABF (mL/min/ 100 g BW)
Group 1	4.2±0.3	3.4±0.3a	-21.3±2.6
Group 2	3.7±0.2	3.1±0.2a	-16.8±2.5
Group 3	4.1±0.3	4.2±0.3	2.1±0.1
AR (kPa/mL/ min/100 g BW)
Group 1	3.1±0.1	2.4±0.1a	-21.0±2.3
Group 2	3.5±0.1	2.7±0.1a	-21.7±2.3
Group 3	3.3±0.2	3.2±0.2	-0.4±0.1

Group 1: liver-innervated rats; group 2: liver-denervated rats; and group 3: control rats. CVP, central venous pressure; MAP, mean arterial pressure; ABF, aortic blood flow; AR, aortic resistance. ^aP<0.05 vs pre-injection.

Table 3 Changes in MAP, ABF and AR following intraportal injection of microspheres (5.6×106) and infusion of Haemaccel (2 mL) via the jugular vein in group 5 of experiment 2.

	Basal	Microsphere injection	Haemaccel injection
MAP (kPa)	12.8±0.5	7.6±0.3b	11.6±0.4ad
ABF (mL/min/ 100 g body weight)	4.4±0.2	3.4±0.2b	5.6±0.4bd
AR (kPa/mL/min/ 100 g body weight)	2.9±0.1	2.3±0.1b	2.1±0.1b

MAP, mean arterial pressure; ABF, aortic blood flow; AR, aortic resistance.

^aP<0.05;

^bP<0.01 vs Basal.

^dP<0.01 vs Microsphere injection.