Diagnostic accuracy of serum biochemical fibrosis markers in children with chronic hepatitis B evaluated by receiver operating characteristics analysis

Table 1 Initial characteristics of children with chronic hepatitis B

Parameters	Mean	SD	Minimum	Maximum
Age (yr)	10	3.41	4	17
ALT (IU/L)	84	57	12	312
AST (IU/L)	68	37	27	264
GGT (IU/L)	15	9	3	69
Bilirubin (μmol/L)	10.26	4.45	2.74	32.83
APO A-I (g/L)	1.14	0.3	0.5	1.77
HPT (g/L)	0.58	0.36	0.31	1.69
A2M (g/L)	2.27	0.57	1	3.59
Staging	1.9	0.56	1	3
Grading	1.49		0.56	1

Table 2 Diagnostic value of serum markers for predicting advanced fibrosis

Markers	Cut-off	Se	Sp	PPV	NPV	AUC	P values
	(g/L)	(%)	(%)	(%)	(%)
APO A-I	1.19	85.7	60.7	21.4	97.1	0.7117	0.035
HPT	1.01	14.3	87.5	12.5	89.1	0.3878	NS
A2M	1.79	100	23.2	14	100	0.5268	NS

Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under curve; NS: no statistical significance.

Table 3 Diagnostic values of serum markers for predicting advanced inflammation

Markers	Cut-off	Se	Sp	PPV	NPV	AUC	P values
	(g/L)	(%)	(%)	(%)	(%)
APO A-I	0.87	89.7	20.6	49.1	70.0	0.3803	NS
HPT	0.59	34.5	70.6	50.0	55.8	0.4701	NS
A2M	1.6	96.6	14.7	49.1	83.3	0.3813	NS

Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under curve; NS: no statistical significance.